Synovİal sarcoma İn a dog

Ankara Üniv Yet Fak Derg, 50, 251-252, 2003
Kısa Bilimsel Çalışma / Short Communication
Synovİal sarcoma İn a dog
Tolga GÜVENÇ, Zafer ÖZYILDIZ, Ümit H. MİLLİ
Department of Pathology, Faculty of Yeterinary Medicine, Ankara University, Ankara
Summary: A case of synovial sarcoma in left tarsal joint and metastases of lung at a 10-year-old male mixed breed dog was
described. Macroscopically, the tumour mass was 5x4x1.5 cm in size and nodules, 0.5-to-3 cm in size, were seen on the lungs. In
microscopical examination, the mass, composed of synovioblastic cells, was diagnosed as synovial sarcoma. Similar tumour cells
were seen in the lungs.
Key words: Dog, synovial sarcoma
Bir köpekte sinovial sarkom
Özet: i O yaşlı melez erkek köpeğin sol tarsal ekleminde gözlenen sinovial sarkom olgusu ve akciğer metastazları tanımlandı.
Makroskobik olarak, sol tarsal eklem üzerindeki tümör kitlesi 5x4x1.5 cm ölçülerindeydi ve akciğer üzerinde 0.5-3 cm boyutlarında
nodüller gözlendi. Mikroskobik incelemede, sinovioblastik hücrelerden oluştuğu gözlenen kitleye sinovial sarkom tanısı kondu. Benzer tümör hücreleri akciğerlerde de gözlendi.
Anahtar kelimeler: Köpek, sinovial sarkom
Synovial sareoma is a rarely diagnosed neoplasm of
dog (5). It has been reported most eommonly in aged, large
formaldehyde
solution and embedded
in paraffin wax.
Seetions were eut at 5-6 ı.ım and stained with haematoxylin
breed male dogs, whieh affeets the stifle and elbow (4).
and eosin. Immunohistochemieally,
The tumour spread by loeal extension along fascial planes
eytokeratin were used to eharaeterization
and tendon sheats and by via vaseular ehannels is believed
celIs. Microscopieally,
to arise from primitiye
synovioblastic
mesenehymal
preeursor
eelIs
vimentin, desmin and
of the tumour
the neoplasm was composed of
elements
(Figure
la).
Cytoplasms
of
outside the synovial membrane of joints and bursae (4,5).
synovioblastie eelIs were eosinophilic and nudei of these
MicroscopiealIy, synovial sareoma is charaeterized by the
eelIs were large, pleomorphie and vesieular. Tumour eelIs
s)'novioblastie eomponent and fibrosarcomatous eomponent
were separated by thin fibrous septa. Giant eelI formations
(1-5). Both eelIular elements are seen in biphasic synovial
were not seen and mitotic figures were less in number.
sarcomas.
Immunohistochemieally,
On the other
sarcomas are eomposed
hand,
monophasic
of onlyone
elements, usualIy the fibroblastic
synovial
of these eelIular
eomponent
(6). Cleft
tumour eelIs were virrientin and
cytokeratin positive but desmin negatiye (Figure lb and c).
The cytokeratin staining was limited to small dusters of
formation, giant eelIs and nodular tumour projeetions of
eelIs
synovium might be frequent1y seen as a histologie features
metastases, composed of similar celIs, were seen in the
of the tumour (1-6).
lung s (Figure 2). According to these histopathological and
The aim of this study is to determine the pathological
findings of synovial sareoma encountered in a lO-year-old
male mixed breed dog.
At necropsy, the tumour mass on the left tarsal joint
but
diffusely
immunohistoehemieal
positive
for
vimentin.
Tumour
features, tumour was diagnosed as a
synovial sareoma.
In the literature, giant celIs, deft formations
and
nodular tumour projections of synovium has been reported
was grayish in color, 5x4x1.5 cm in size and in the lung s
(1,2,4,6). However, in this ease none of these findings were
white in color, round to ovoid in shape masses were
presenL Most of observed synovial sareomas were biphasic
observed. Tissue speeimens were fixed in 10% buffered
(1,2), but this case was monophasie
synovial sareoma.
252
Tolga Güyenç - Zafer Özyıldız - Ümit H. Milli
Figure 1. a. SynoYioblastie tumour eeııs on the left tarsal joint. HxE, x260. b. Vimentin positiye tumour eeııs, aYidin-biotin
peroxidase teehnique. x260. e. Cytokeratin positiye tumour eeııs, aYidin-biotin peroxidase teehnique. x260.
References
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.
Geliş tarihi: 23.12.2002/
Correspondence
address:
Dr. Tolga Güvenç
Ankara Üniversitesi, Veteriner Fakültesi
Patoloji Anabilim Dalı
06110 Dışkapı, Ankara
Figure 2. Metastatic tumour eeııs in the lung. HxE, x60.
Monophasic synovial sarcomas are usually composed to
fibrablastic components
(5,6). In the present case, only
synovioblastic components were seen. Synovial sarcomas
are often locally invasive and metastasis to heart, lungs,
kidneys, spleen, hver and regional lymph nodes has been
reported (1,2,4). In the present case, only lung metastasis
was observed.
i
Kabul tarihi: 31.12.2002