biolegend.com

Chemokine Receptor Biology
04-0021-00
INFLAMMATION
HOMEOSTASIS
Bone Marrow
Periphery
CXCR4
Rolling Neutrophil
CXCR4
LFA-1
ICAM-1
CXCR1, 2
CXCL8
Blood Vessel
T Progenitor
CCR7
CCR7
Bone Marrow
Niche
CCR9
CCL19
CCL25
CCL21
CD34
HSC
IFN-γ
Pro-inflammatory CXCL8
Cytokines
TNF-α
IL-1
Thymus
Tissue
CXCL8
Positive
Selection
Egress
Medulla
Cortex
Single Positive
Thymocyte
CCL19, 21
CCL20
CXCR4
CXCR1
CXCL1, 2, 3,
5, 6, 7, 8
CCR8
CCR9
CXCL9, 10, 11
CCL2
Chemokine
Sequestration
Chemokine Receptor Signaling
HIV
?
CXCL11, 12
CXCL16
Extracellular
CXCR6
CCR5
Viral CCL1, 2, 3
Respiratory Burst
Granule Release
CCL2, 3, 5
17, 22
CCL5, 7, 11,
13, 14, 15,
24, 26
CCR4
CXCL13
CXCR4
CXCL12
XCR1
XCL 1,2
STK’s, Ras
Cytoskeletal Remodeling
Shape Change
Firm Adhesion
CX3CR1
Block Recruitment of
Dendritic Cells,
Lymphocytes
Receptor
Internalization/
Desensitization
KSHV
CCL3, 4, 5, 7
14, 15, 16
E1
CXCL1, 5, 7
US28
CXCL12: SDF-1
CXCL4: PF-4
CXCL8: IL-8
CXCL13: BCA-1, BLC
CXCL9: CMK, MIG, SCYB9
CXCL14: BRAK, Bokeline
CXCL10: IP-10
CXCL15: LUNGKINE, SCYB15
CXCL11: I-TAC
CXCL16: SCYB16, SR-PSOX
Angiogenesis
Tumor Cells
CCL2, 3,
4, 5, 7
Blood Vessel
CCL2, 3, 4, 5
Tumor Metastasis
CXCL1, 8,
10, 12
CCL11
Recruitment
CCR7: Breast, Melanoma, Head and Neck, Colorectal, Chronic Lymphocytic
Leukemia, Stomach, Non-Hodgkin’s Lymphoma, T Cell Leukemia
CCR9: Melanoma
CCR10: Melanoma
CXCR3: Acute Lymphoblastic Leukemia
CXCR4: Breast, Ovarian, Prostate, Pancreatic, Melanoma, Oesophageal,
Non-small Cell Lung, Head and Neck, Bladder, Colorectal, Osteosarcoma,
Neuroblastoma, Acute Lymphoblastic Leukemia, Chronic Lymphocytic
Leukemia, Stomach
We would like to thank Dr. Albert Zlotnik, University of California, Irvine for his contributions to this poster.
CXCL7: NAP-2
CXCL12
Upregulation of
Chemokine Receptors
CXCR4
Interactive Poster: biolegend.com/chemokinebiology
CXCL3: GRO3, GRO-γ, MGSA-γ,
MIP-2β, SCYB3
Immunosuppression
Hypothetical Primary Tumor Site
ECRF3
UL12
CCR1
Treg Recruitment
Metastasis/Angiogenesis
VEGF
9727 Pacific Heights Blvd. San Diego, CA 92121 | Email: [email protected]
CXCR5: Head and Neck Cancer
US & Canada Toll-Free: 1.877.246.5343 (877-BIOLEGEND) | International: 1.858.768.5800
CXCL6: SCYB6, GCP 2, CKA-3
CCR7, 10
CXCL1, CXCL8
CCL26, CX3CL1
biolegend.com
Kaposi Sarcoma Virus
Immunosuppression
CXCL5: ENA-78, LIX
CCL28
CXCR4
CCR2
CCL2, 7, 8
12, 13
CCR8
Arrestin,
PLCβ2
PLCβ2,
PLD, PKC
CCR4
Treg, Th2
Recruitment
CXCL2: CINC-2α, GRO2, GROβ,
GROB, MGSA-β, MIP2
CCR7
CCL27, CXCL14
Tumor Cells
CXCR5
Membrane
Immunosuppression
CD4
CXCL1: GRO1, GROα, MGSA, NAP3,
SCYB1, MGSA-α
Dendritic Cell
Oxysterols
CXCR7
Chemokine Receptor
CCR3
Immune Tolerance
Chemokine Nomenclature
CANCER
Tumor Defense
CXCL14
G Proteins
US28
Endothelial Cell
CXCR7
CX3CR1
CCR9
α4β7+ T cell
?
CXCR3
Cytomegalovirus
CCR8
CXCR6
Small Intestine
Skin: CCL27, CXCL14
CLA+ T cell
?
CCL5
Macrophage
Dendritic Cell
CCR10
CCR7
CCL3, 4, 5,
8, 14
B cell
CCL25
Intracellular
CD4
CCR5
?
Tumor Cell Proliferation
CCL19, 21
CCL2, 3, 5, 7
CXCL17
CCR10
Reduced
Recruitment
HIV
CCL27
CCL18
T Cell
CCR2
D6
CCL19
T cell
Small Intestine:
CCL25, CXCL17
Dermal Cells
Chemokine
CXCR2
CD4
CCR7
Spleen: CCL19, CCL21, CXCL13
Liver: CXCL13
CXCL17
+
CCL27, 28
CCR7
CXCL6, 8
Macrophage
CCR2
CCR3
Atypical
Lymph Nodes:
CCL19, CCL21, CXCL13
Bone Marrow: CXCL12
Mature CD4 or CD8 Naïve T Cell
+
CCL25
CCL1, 4
CCR6
B cell
HEV
Skin
Negative
Selection
Epithelium
Chemokine Sink
CXCR4
CD4+ or CD8+
CCR7+, CCR9+
CD4+CD8+ Thymocyte
Injury, Infection
CXCR5
Brain: CXCL12, CXCL14
Lungs: CXCL12, CXCL17
G-CSF
Sphingosine1-Phosphate
Receptor
Cortico-medullary
Junction
CXCR4+, CCR7+, CCR9+
CD4-CD8Thymocyte
Chemokine Gradient
Other Reported HIV Co-Receptors
CXCR5
T cell
CXCL13
CXCL12
Endothelium
+
CCR5
T cell Zone
Endothelium
Blood
Endothelium
HIV
DUFFY
CCL21
PSGL-1
P-Selectin
HIV Entry
Follicle
CCR9
E-Selectin
VIROLOGY
CXCL1, 8
CCL2, 5
T Progenitor
Specialized Stromal Cells
Sphingosine-1-Phosphate
Gradient
Secondary Lymphoid Tissues
Hypothetical
Secondary
Tumor Site
CXCL17: DMC, VEGF Co-regulated
Chemokine 1
CCL1: I-309, TCA-3, SCYA1
CCL6: C10, MRP1
CCL12: MCP-5
CCL17: TARC, ABCD 2
CCL22: MDC, ABCD 1
CCL27: CTACK, ESKine, ILC, Skinkine
Th17: CCR4, 6
Cell Expression
Dendritic Cells: CCR1, 2, 5, 6, 7; CXCR1, 2, 4
Eosinophils: CCR3, CXCR4
CCL7: MCP-3, MARC
CCL13: MCP-4
CCL18: DC-CKA1, PARC, MIP-4, AMAC-1
CCL23: MIP-3, CKb-8, MPIF-1
CCL28: MEC, CCK1
Th22: CCR4, 6, 10
Hematopoietic Stem Cells: CXCR4
CCL3: MIP-1α
CCL8: MCP-2, HC14
CCL14: HCC-1, HCC-3, MCIF, NCC2
CCL19: ELC, MIP-3β, Exodus-3
CCL24: MPIF-2, Eotaxin-2, CKβ-6
Tfh: CXCR5
Naïve T Cells: CCR7, CXCR4
CCL4: MIP-1β, ACT-2, H400
CCL9: CCL10, MRP-2, MIP-1γ, CCF18
CCL15: MIP-1δ, MIP 5, MRP-2B, NCC3, HCC-2
CCL20: LARC, MIP-3α, Exodus-1
CCL25: TECK, CKβ-15
T Helper Cell Expression
Natural Killer Cells: CCR2, 4, 5, 8;
CXCR1, 3, 4; CX3CR1
Mast Cells: CCR1, 3, 4, 5; CXCR1-4
CX3CL1: Fractalkine, Neurotactin
CCL2: MCP-1, MCAF, JE
Treg: CCR2, 4, 5, 6, 8-10; CXCR4-6
B Cells: CCR7, CXCR4, 5; CX3CR1
Neutrophils: CCR1; CXCR1, 2, 4
Epithelial Cells: CCR1-8; CXCR1, 4
CCL5: RANTES
CCL11: Eotaxin, Eotaxin 1
CCL16: HCC-4, LEC, LCC-1
CCL21: SLC, 6Ckine, Exodus-2
CCL26: Eotaxin-3
XCL1: Lymphotactin, ATAC, SCM-1α
XCL2: SCM-1β
Th1: CCR5, CXCR3
Th2: CCR3, 4, 8; CXCR5
Macrophages: CCR1, 2, 5; CXCR1, 4
Basophils: CCR1-4, CXCR4
Endothelial Cells: CCR1-4; CXCR1-4