ozgur oktem md - School of Medicine

OZGUR OKTEM MD
Associate Professor of Obstetrics and Gynecology
Department of Obstetrics and Gynecology
School of Medicine Koc University
Istanbul, TURKEY
Personal information
 Address:
KOC UNIVERSITY
Department of Obstetrics and Gynecology School of Medicine,
Office Z70 Rumelifeneri Yolu 34450 Istanbul Turkey
Tel office: 02123381071
Mobile: 05339553830
E-mail: [email protected]
AMERICAN HOSPITAL
Women’s Health Center Assisted Reproduction Unit
Guzelbahce Sok. No:20 Nisantasi Istanbul Turkey
Tel office: (+90) 212 444-3-777 (ext 7877)
Mobile: (+90) 533-955-3830
E-mail: [email protected]
 Date of birth: 08.01.1971
1
Medical Education
1989-1996
Erciyes University, School of Medicine, Kayseri Turkey
Residency
1997-2001
Residency in Obstetrics and Gynecology, Department of Obstetrics
and Gynecology, School of Medicine
Marmara University Istanbul Turkey
Postdoctoral Fellowship
2003-2005/2006-2008 Center for Reproductive Medicine and
Infertility, Weill Medical College of Cornell University New York,
NY, USA
2005-2006
Visiting Scientist, Memorial Sloan Kettering Cancer Center Cell
Biology Program and Developmental Biology Program Molecular
Cytology Core Facility New York, NY USA
Work Experience
2008-2012
Specialist of Obstetrics and Gynecology and Reproductive
Endocrinology and Infertility
Director, Fertility Preservation Program
American Hospital, Istanbul Turkey
Women’s Health Center Assisted Reproduction Unit
2013-
Associate professor of Obstetrics and Gynecology
Koc University School of Medicine, Istanbul Turkey
2
Certifications:
Reproductive endocrinology and infertility
Clinical Embryology, Assisted Reproductive Techniques, IVF laboratory
ECFMG
Awards
The President’s award in the 2008 meeting of the Society for Gynecologic Investigations
(Follicle Stimulating Hormone Regulates Granulosa Cell Mitosis through C-Jun N
Terminal Kinase (JNK) Pathway). San Diego, USA
Grants
The Scientific and Technological Research Council of Turkey - TÜBİTAK
Project title: Comparison of c-jun-n-terminal kinase activity (JNK) and cyclin D levels in
the sera and follicular fluids of good vs. poor responding patients undergoing assisted
reproduction: deciphering the role of FSH-induced JNK activation in granulosa cell
kinetics and follicle growth
Project number: 109S164 March 2009
Areas of Research Interest
Folliculogenesis: Early stages of follicle growth and factors controlling it.
Poor responder IVF patients: Ovarian follicle dynamics and the paracrine factors
controlling follicle’s response to FSH
Cryobiology: Vitrification vs. slow freezing, ovarian tissue freezing
Polycystic ovarian syndrome and BMP-4 signaling
Fertility preservation strategies
Human ovarian xenograft models to assess the impact of chemotherapy agents on the
ovary and neovascularization process
JNK and mTOR signaling pathways in proliferation and invasion of granulosa cell tumors
of the ovary
3
Sphingosine-1-phosphate signaling in the ovary
GnRH signaling pathway in granulosa cell tumors
Mentorships, Translational Research Projects and Clinical Trials
1. The expression of receptor tyrosine kinase /PI3K/AKT/mammalian target of
rapamycin (RTK/PI3K/AKT/mTOR) signaling pathway in granulosa cell tumors of the
ovary, and its correlation with histological and clinical parameters of tumor aggressivity.
2. The role of intracellular glutathione stores enriched with N-acetyl-cystein (NAC) in
reducing cyclophosphamide induced ovarian toxicity in rats.
3. The impact of antimetabolite cancer drug gemcitabine on ovarian toxicity:
histomorphometric study.
4. Bone morphogenetic protein-4 (BMP-4 signaling) levels in the sera and follicular fluids
of patients with polycystic ovarian syndrome.
5. Three-dimensional culture of human preantral follicles: A new model for in vitro
growth.
6. Comparison of slow freezing and vitrification in human ovarian tissue
cryopreservation.
7. MAPK pathways in FSH induced follicular growth and granulosa cell cycle kinetics in
human.
8. Sphingosine signaling pathways in human ovary and as an antiapoptotic agent in
ovarian tissue freezing to prevent cryodamage.
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9. Comparison of GnRH agonist and antagonist cycles in normo-responder IVF patients.
10. Comparison of first trimester screening profiles of spontaneous and IVF pregnancies.
11. cJun-N-Terminal kinase (JNK) pathway in normal vs. poor responder IVF patients,
preantral follicle growth and granulosa cell cycle progression.
Invited lectures
1. Transplantation biology and fertility preservation: advances in ovary function and
oocyte survival Department Of Obstetrics, Gynecology and Reproductive Sciences
Yale School of Medicine October 10th 2006, New Haven, Connecticut USA
2. Collection, processing and storage of ovarian tissue: Clinical indications and best
practice 8th Biennial meeting of Alpha Scientists Budapest - Hungary
30th April - 02nd May 2010
3. Meme kanserli premenopozal hastada fertilitenin korunması 3. Ulusal üreme
endokrinolojisi ve infertilite kongresi 7-10 Ekim 2008 Antalya, Türkiye (Fertility
preservation in premenopausal women with breast cancer the third Biannual Meeting of
the Turkish Society of Reproductive Medicine 7-10 October, 2008 Antalya)
4. Quantitative assessment of the impact of chemotherapy on ovarian function and
reserve and strategies to prevent it. Video Workshop in Gynecologic Oncology, 12-14
Şubat 2009 Bilkent Otel, Ankara, Turkey
5. Fertility Preservation Strategies and Ovarian Tissue Freezing, 10th October, 2010
American Hospital, Istanbul, Turkey
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6. Controlled ovarian stimulation as a fertility preservation strategy, the fourth Biannual
Meeting of the Turkish Society of Reproductive Medicine 15-19 October, 2010 Antalya,
Turkey
7. Proteomics markers and risk stratification in patients with polycystic ovarian
syndrome. Turkish Society for Obstetrics and Gynecology, 20 February 2011, Harbiye
İstanbul, Turkey
8. Folliculogenesis from the perspective of reproductive endocrinology 5th annual
meeting of Turkish Society for Reproductive Medicine 27-30 September 2012, Antalya,
Turkey
9. Ovarian Aging Yeni Yüzyıl Üniversity Medical School Feb, 2013, Istanbul
10. Fertility Preservation in Breast Cancer Patients, Uludağ Obstetri-Jinekoloji Kış
Kongresi Mart 2013 Bursa
11. Fertility Preservation in Cancer Patients, Uludağ Obstetri-Jinekoloji Kış Kongresi Mart
2013 Bursa
12. How to write the material and emthod section of a scientific paper Uludağ ObstetriJinekoloji Kış Kongresi Mart 2013 Bursa
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Peer-Reviewership in Scholarly Journals
Human Reproduction Update
Fertility and Sterility
Human Reproduction
Reproductive Biomedicine Online
European Journal of Obstetrics & Gynecology
Gynecological Endocrinology
Reproductive Biology and Endocrinology
International Journal of Gynecology & Obstetrics
Archives of Andrology (System Biology in Reproductive Medicine)
American Journal of Physiology-Endocrinology and Metabolism
Memberships
American Society for Reproductive Medicine
European Society for Human Reproduction
Society for Gynecologic Investigations
The Society for the Study of Reproduction
Alpha Scientists in Reproductive Medicine
New York Academy of Science
Postdoctoral Association of New York
The Society for Cryobiology
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Peer-Reviewed Articles
1: Mercan R, Oktem O, Salar Z, Nuhoglu A, Balaban B, Urman B. Conjoined twins
after intracytoplasmic sperm injection and transfer of day-3 embryos. Fertil
Steril. 2011 Aug;96(2):e111-4. Epub 2011 Jul 1. PubMed PMID: 21722896.
2: Balaban B, Yakin K, Alatas C, Oktem O, Isiklar A, Urman B. Clinical outcome of
intracytoplasmic injection of spermatozoa morphologically selected under high
magnification: a prospective randomized study. Reprod Biomed Online. 2011 Feb 15.
[Epub ahead of print] PubMed PMID: 21324747.
3: Oktem O, Alper E, Balaban B, Palaoglu E, Peker K, Karakaya C, Urman B.
Vitrified human ovaries have fewer primordial follicles and produce less
antimüllerian hormone than slow-frozen ovaries. Fertil Steril. 2011 Jun
30;95(8):2661-4.e1. Epub 2011 Feb 5. PubMed PMID: 21300348.
4: Oktem O, Buyuk E, Oktay K. Preantral follicle growth is regulated by
c-Jun-N-terminal kinase (JNK) pathway. Reprod Sci. 2011 Mar;18(3):269-76. Epub
2010 Oct 19. PubMed PMID: 20959642.
5: Oktem O, Urman B. Options of fertility preservation in female cancer patients.
Obstet Gynecol Surv. 2010 Aug;65(8):531-42. Review. PubMed PMID: 20955632.
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6: Oktem O, Urman B. Understanding follicle growth in vivo. Hum Reprod. 2010
Dec;25(12):2944-54. Epub 2010 Oct 11. Review. PubMed PMID: 20937745.
7: Sönmezer M, Cil AP, Oktem O, Oktay K. Breast cancer diagnosis following
ovarian stimulation: are the tumours different? Reprod Biomed Online. 2010
Aug;21(2):266-71. Epub 2010 May 31. PubMed PMID: 20615755.
8: Oktem O, Kucuk M, Ozer K, Sezen D, Durmusoglu F. Relation of body fat
distribution to femoral neck bone density and endometrial thickness in
postmenopausal women. Gynecol Endocrinol. 2010 Jun;26(6):440-4. PubMed PMID:
20175708.
9: Oktem O, Oktay K. Fertility preservation for breast cancer patients. Semin
Reprod Med. 2009 Nov;27(6):486-92. Epub 2009 Oct 5. Review. PubMed PMID:
19806518.
10: Oktem O, Oktay K. Stem cells and reproductive medicine. Minerva Ginecol. 2009
Aug;61(4):247-52. Review. PubMed PMID: 19745792.
11: Oktem O, Urman B. Xenografting fresh and cryopreserved human ovarian tissue.
Fertil Steril. 2009 May;91(5):e7-8; author reply e9. Epub 2009 Apr 1. PubMed
PMID: 19342019.
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12: Oktem O, Oktay K. Current knowledge in the renewal capability of germ cells
in the adult ovary. Birth Defects Res C Embryo Today. 2009 Mar;87(1):90-5.
Review. PubMed PMID: 19306347.
13: Oktay K, Oktem O. Fertility preservation medicine: a new field in the care of
young cancer survivors. Pediatr Blood Cancer. 2009 Aug;53(2):267-73. Review.
PubMed PMID: 19301406.
14: Roberts JE, Nikolopoulos SN, Oktem O, Giancotti F, Oktay K. Integrin beta-4
signaling plays a key role in mouse embryogenesis. Reprod Sci. 2009
Mar;16(3):286-93. Epub 2008 Dec 15. PubMed PMID: 19087978.
15: Oktay K, Oktem O. Ovarian cryopreservation and transplantation for fertility
preservation for medical indications: report of an ongoing experience. Fertil
Steril. 2010 Feb;93(3):762-8. Epub 2008 Nov 14. PubMed PMID: 19013568.
16: Oktem O, Oktay K. Preservation of menstrual function in adolescent and young
females. Ann N Y Acad Sci. 2008;1135:237-43. Review. PubMed PMID: 18574230.
17: Oktem O, Oktay K. Stem cells: a perspective on oocytes. Ann N Y Acad Sci.
2008 Apr;1127:20-6. Review. PubMed PMID: 18443325.
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18: Oktem O, Oktay K. The ovary: anatomy and function throughout human life. Ann
N Y Acad Sci. 2008 Apr;1127:1-9. Review. PubMed PMID: 18443323.
19: Oktay K, Buyuk E, Oktem O, Oktay M, Giancotti FG. The c-Jun N-terminal kinase
JNK functions upstream of Aurora B to promote entry into mitosis. Cell Cycle.
2008 Feb 15;7(4):533-41. PubMed PMID: 18431843.
20: Reh A, Oktem O, Oktay K. Impact of breast cancer chemotherapy on ovarian
reserve: a prospective observational analysis by menstrual history and ovarian
reserve markers. Fertil Steril. 2008 Nov;90(5):1635-9. Epub 2007 Dec 31. PubMed
PMID: 18166178.
21: Oktem O, Oktay K. A novel ovarian xenografting model to characterize the
impact of chemotherapy agents on human primordial follicle reserve. Cancer Res.
2007 Nov 1;67(21):10159-62. PubMed PMID: 17974956.
22: Oktem O, Oktay K. Quantitative assessment of the impact of chemotherapy on
ovarian follicle reserve and stromal function. Cancer. 2007 Nov
15;110(10):2222-9. PubMed PMID: 17932880.
23: Oktay K, Sönmezer M, Oktem O, Fox K, Emons G, Bang H. Absence of conclusive
evidence for the safety and efficacy of gonadotropin-releasing hormone analogue
treatment in protecting against chemotherapy-induced gonadal injury. Oncologist.
2007 Sep;12(9):1055-66. Review. PubMed PMID: 17914075.
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24: Oktay K, Oktem O. Regeneration of oocytes after chemotherapy: connecting the
evidence from mouse to human. J Clin Oncol. 2007 Aug 1;25(22):3185-7. PubMed
PMID: 17664463.
25: Oktem O, Oktay K. The role of extracellular matrix and activin-A in in vitro
growth and survival of murine preantral follicles. Reprod Sci. 2007
May;14(4):358-66. PubMed PMID: 17644808.
26: Oktem O, Paduch DA, Xu K, Mielnik A, Oktay K. Normal female phenotype and
ovarian development despite the ovarian expression of the sex-determining region
of Y chromosome (SRY) in a 46,XX/69,XXY diploid/triploid mosaic child conceived
after in vitro fertilization-intracytoplasmic sperm injection. J Clin Endocrinol
Metab. 2007 Mar;92(3):1008-14. Epub 2006 Dec 12. PubMed PMID: 17164312.
27: Oktay K, Oktem O, Reh A, Vahdat L. Measuring the impact of chemotherapy on
fertility in women with breast cancer. J Clin Oncol. 2006 Aug 20;24(24):4044-6.
PubMed PMID: 16921067.
28: Oktay K, Hourvitz A, Sahin G, Oktem O, Safro B, Cil A, Bang H. Letrozole
reduces estrogen and gonadotropin exposure in women with breast cancer undergoing
ovarian stimulation before chemotherapy. J Clin Endocrinol Metab. 2006
Oct;91(10):3885-90. Epub 2006 Aug 1. PubMed PMID: 16882752.
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29: Saxena BB, Zhu L, Hao M, Kisilis E, Katdare M, Oktem O, Bomshteyn A, Rathnam
P. Boc-lysinated-betulonic acid: a potent, anti-prostate cancer agent. Bioorg Med
Chem. 2006 Sep 15;14(18):6349-58. Epub 2006 Jun 13. PubMed PMID: 16777417.
30: Oktay K, Sonmezer M, Oktem O. 'Ovarian cryopreservation versus ovarian
suppression by GnRH analogues: primum non nocere': reply. Hum Reprod. 2004
Jul;19(7):1681-3. Review. PubMed PMID: 15220313.
31: Oktem O, Dedeoğlu N, Oymak Y, Sezen D, Köksal L, Pekin T, Gökaslan H, Kavak
ZN. Maternal serum, amniotic fluid and cord leptin levels at term: their
correlations with fetal weight. J Perinat Med. 2004;32(3):266-71. PubMed PMID:
15188803.
32: Gökaslan H, Oktem O, Durmuşoglu F, Eren F. Apoptosis in the endometrium of
postmenopausal women receiving tibolone. Gynecol Obstet Invest. 2003;56(3):124-7.
Epub 2003 Sep 22. PubMed PMID: 14504425.
33: Oktem O, Gökaslan H, Durmusoglu F. Spontaneous uterine rupture in pregnancy 8
years after laparoscopic myomectomy. J Am Assoc Gynecol Laparosc. 2001
Nov;8(4):618-21. PubMed PMID: 11677352.
34: Başbuğ M, Aygen E, Tayyar M, Tutuş A, Kaya E, Oktem O. Correlation between
maternal thyroid function tests and endothelin in preeclampsia-eclampsia. Obstet
Gynecol. 1999 Oct;94(4):551-5. PubMed PMID: 10511357.
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35: Başbuğ M, Aygen E, Tayyar M, Kaya E, Narin F, Oktem O. Hyaluronic acid plus
heparin for improved efficacy in prevention of adhesion formation in rat uterine
horn model. Eur J Obstet Gynecol Reprod Biol. 1998 May;78(1):109-12. PubMed
PMID:9605460.
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International Book Chapters
Bulent Urman, Ozgur Oktem, Başak Balaban. Embryo cryopreservation and alternative
strategies for controlled ovarian hyperstimulation in textbook Fertility preservation:
emergency technologies and clinical applications Editors: E. Seli, A. Agarwal Springer,
2012
Ozgur Oktem, Kutluk Oktay. Recent Advances in Fertility Preservation for the Female.
Biennial Review of Infertility. Editors: Carrell, D.T.; Racowsky, C.; Schlegel, P.N.; Van
Voorhis, B.J.
Humana Press 2009
Ozgur Oktem, Kutluk Oktay. Fertility Preservation in Women with Cancer. Female
Reproductive and Sexual Medicine. Humana Press 2009
Ozgur Oktem, Kutluk Oktay. Preservation of fertility: Current concepts and strategies.
Reproductive Endocrinology and Infertility: The Practical Clinical and Laboratory Editors
C. Matthew Peterson, Doug Carrell. Humana Press 2009
Erkan Büyük, Ozgur Oktem, Murat Sonmezer, Kutluk H. Oktay. Ovarian tissue
cryopreservation and other fertility preserving strategies. Textbook of Assisted
Reproductive Techniques.eds:David K. Gardner, Ariel Weissman, Colin M Howles and
Zeev Shoham 3rd Edition
Ozgur Oktem, Kutluk Oktay. Assessment of Human Reproductive Function. Editör Carla
Bulletti. 2008 Vol:1127 Wiley, John & Sons
Ozgur Oktem, Murat Sonmezer, Kutluk H. Oktay. Ovarian tissue cryopreservation and
other fertility preserving strategies. Textbook of Assisted Reproductive Techniques.eds:
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David K. Gardner, Ariel Weissman, Colin M Howles and Zeev Shoham 2nd Edition July
2004
National Book Chapters
Bülent Urman, Özgür Öktem. “Jinekolojik kanserlerde fertilite preservasyon”. Jinekolojik
Onkoloji, Editör: Ali Ayhan Güneş Yayınevi, Ankara, syf: 205-212, 2012
Özgür Öktem, Bülent Urman. ”Kanserli Hastada Fertilitenin Korunması”. Kanser
Hastasına Yaklaşım: Tanı, Tedavi ve Takipte Sorunlar, Editörler: Prof. Dr.Nil Molinas
Mandel, Prof. Dr. Haluk Onat Nobel Kitabevi, 2. Baskı, İstanbul, syf:345-354, 2012
Özgür Öktem. “Üreme tıbbı perspektifinden kök hücreler”. Yardımcı Üreme Teknikleri
Temel Klinik ve Embryolojik Uygulamalar. Editor: Prof. Dr. Önder Çelik Nobel Kitabevi,
Adana, syf: 801-804, 2011
Melahat Dönmez Kesim, Özgür Öktem. “Fetusun antenatal değerlendirilmesi”.
Neonatolojinin temel ilkeleri ve acilleri. Editor: Müyesser Tuncer, Eren Özek Güneş
Kitabevi, İstanbul, syf: 16-26, 2007
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Abstracts
1. O. Oktem, T. Barut, E. Palaoglu, B. Urman, B. Uncomplicated singleton
pregnancies conceived spontaneously and through assisted reproduction
technologies (ART) have comparable first trimester screening profiles for Down
syndrome" Fertil Steril 2010;94:S27
2. O. Oktem, R. Mercan, B. Başaban, B. Urman. Comparison of IVF outcomes
between GnRH antagonist and GnRH agonist long protocols in normo responder
IVF patients Fertil Steril 2010;94:S260
3. O.Oktem, O.Peker, U. Ince, B. Urman Antiapoptotic agent sphingosine-1phosphate protects primordial follicles against cryodamage during
cryopreservation of human ovarian tissue Fertil Steril 2011;96:S214
4. O.Oktem, B. Urman Patients with polycystic ovarian syndrome (PCOS) have
decreased serum levels of theca cell derived bone morphogenetic protein-7
(BMP-7): a new hormonal marker? Fertil Steril 2011;96:S40
5. Oktem O, Yuksel A, Unal F, Boran B, Aral H, Arvas M, Urman B. Antimetabolite
Cancer Drug Gemcitabine Induces Acute Ovarian Toxicity in Mice As Assessed by
Antimullerian Hormone Levels Reprod Sci 2010:144A
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6. Oktem O, Alper E, Peker K, Palaoglu E, Balaban B, Urman B.Vitrified human
ovaries harbor less primordial follicle and produce less AMH than slow frozen
ones. Fertil Steril 2009:92 (3), Supplement, S65-S66
7. Alper E, Oktem O, Palaoglu E, Peker K, Yakin K, Urman B. The impact of
laparoscopic ovarian cystectomy on ovarian reserve as assessed by antral follicle
count and serum AMH levels Fertil Steril 2009; 92: Suppl (1):59
8. Oktem O, Oktay K c-Jun N-terminal kinase (JNK) pathway controls granulosa cell
mitosis: a novel mechanism in regulation of preantral follicle growth
Fertil Steril 2008;90:S330
9. Cil AP, Oktem O, Oktay K. A meta-analytic comparison of oocyte vitrification to
slow freezing: time trends and the current state of the technology
Fertil Steril 2008;90:S269-270
10. Sonmezer M, Oktem O, Cil A, Oktay K.
Breast cancer diagnosis following controlled ovarian stimulation: are the tumors
different? Fertil Steril 2008; 90:S268
11. Oktay K, Oktem O, Barad D, Gleicher N.
Longevity of autologous ovarian transplants: extended experience in humans.
Fertil Steril 2008; 90:S53
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12. Oktem O, Oktay K Follicle Stimulating Hormone Regulates Granulosa Cell Mitosis
Through C-Jun N Terminal Kinase (JNK) Pathway
Reprod Sci 2008;15(Sup):96A (the president’s award in 2008 meeting of the
society for gynecologic investigations).
13. Oktem O, Oktay K Sphingosine-1-Phosphate Enhances Human Primordial Follicle
Survival and Blocks Ovarian Apoptosis In Vitro.
Fertil Steril 2007;88:S270
14. Oktem O, Oktay K Impact of previous chemotherapy on ovarian production of
estradiol, progesterone, and AMH: An in vitro controlled study
Fertil Steril 2007; 88:S14.
15. Elassar A, Oktem O, Oktay K Fertility Preservation with Ovarian
Cryopreservation: A Decade of Experience Fertil Steril 2007; 88:S12-13.
16. Oktay K, Oktem O: Evidence for primordial follicle regeneration postchemotherapy in human ovarian xenografts.
Reprod Sci 14:A790, 2007
17. Oktem O, Liu H Oktay K Evidence for altered ovarian stromal function in women
previously exposed to chemotherapy Fertil Steril 2006;86:S286
18. Oktem O Oktay K Histological quantification of the impact of chemotherapy on
human primordial follicle reserve in women
Fertil Steril 2006;86:S312-313
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19. Oktem O, Turkekul M, Xu K, Rozenwaks Z, Oktay K
Normal female phenotype and ovarian development despite the gonadal
expression of sex determining region of Y chromosome (SRY) in a 46, XX/69, XXY
diploid/triploid mosaic child conceived after IVF-ICSI
Fertil Steril 2006;86:S23
20. Oktem O, Sezen D Oktay K
Correlation of Antimullerian Hormone Levels with Primordial Follicle Count in
Human Ovary (poster presentation, ASRM 2006)
Fertil Steril 2006;86:S402
21. Oktem O Oktay K
A novel ovarian xenografting model to characterize the
impact of chemotherapy agents on human primordial follicle reserve
Fertil Steril 2006;86:S95-S96
22. Reh AE, Oktem O, Lostritto K, Oktay K Impact of breast cancer chemotherapy
on ovarian reserve: a prospective analysis by menstrual history and ovarian
reserve markers
Fertil Steril 2006;86:S97-98
23. The impact of paclitaxel on menstrual function.
Oktay K. Libertella N, Oktem O, Beck L, Cil A. 28th Annual Breast Cancer
Symposium 2005 San Antonio TX (oral presentation)
24. Oktem O Oktay K Role of extracellular matrix, Activin-A and mitogen activated
protein kinase (MAPK) signaling pathways in preantral follicle growth and
survival in the mouse.
Fertil Steril 2005;84(S1):384-385
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25. Roberts JE, Nikolopoulos S, Oktem O, Rozenwaks Z, Giancotti F, Oktay K Integrin
Beta-4 signaling plays a key role in mouse embryogenesis.
Fertil Steril 2005;84(S1):7-8 (oral presentation and best research award in 61st
annual meeting of ASRM 2005)
26. Oktay K, Cil A, Oktem O, Bang H.
Continous Combined Letrozole-FSH stimulation requires less FSH with similar
outcomes compared to standard ovarian stimulation regimens for IVF.
Fertil Steril 2005;84(S1):94
27. Oktay K, Oktem O Sustained endocrine function and spontaneous pregnancy
after transplantation of cryopreserved ovarian tissue in stem cell transplant
recipients.
Fertil Steril 2005;84(S1):68
28. Oktem O, Buyuk E, Oktay K Extracellular signal regulated kinase (ERK) and c-junN-terminal kinase (JNK) regulate preantral follicle growth in the mouse. Annual
meeting of the Society for Gynecologic Investigations, 2004 Houston TX
29. Buyuk E, Oktem O, Roberts J, Rosenwaks Z, Oktay K. In Vitro Growth of Mouse
Primary and Early Preantral Follicles in a 3-Dimensional Culture System.
Fertil Steril 2003;80(S3):79
30. Oktay K, Buyuk E, Oktem O. Deciphering Early Folliculogenesis: Jun Amino
Terminal Kinase (JNK) plays a key role in preantral follicle growth Fertil Steril
2003;80(S3):26-27
31. M.D. Kesim, O.Oktem, G. Mandıracı, O. Aksakal, D. Sakız, L. Köksal The Actions of
Levonorgestrel-Releasing IUD on the Endometrium Already Under the Influence
21
of Tamoxifen in Pre and Postmenopausal Women with Breast Cancer 13th
Annual Meeting of The North American Menopause Society 3-5 October 2002,
Chicago, USA
32. Oktem O, Gokaslan H, Eren F, Durmuşoğlu F Apoptosis in the Endometrium of
the Postmenopausal Women Receiving Tibolone. 12th Annual Meeting of the
North American Menopause Society 4-6 October 2001 New Orleans Lousiana
USA
33. Oktem O, Durmusoglu F, Ozer K Relation of body fat distribution to bone mineral
density and endometrial thickness in postmenopausal women 11th Annual
Meeting of the North American Menopause Society 7-9 September 2000
Orlando Florida USA,
34. Gokaslan H, Oktem O, Kavak Z, Durmusoglu F, Ahiskali R
Unique Metastasis of the Breast Carcinoma to Uterine Leiomyoma.
XIXth Gynecopathology Congress Zeynep Kamil Maternity Hospital 6-8 Haziran
2001 İstanbul, Turkiye
35. Kavak Z, Oktem O, Ceyhan N A Sudden Onset of Dysarthria in a Pregnant
Women, A Case of Clival Chordoma. 5th World Congress of Perinatal Medicine
23-27 September, 2001 Barcelona, Spain
36. Oktem O, Kavak Z. First Trimester Screening Using The Combination of Nuchal
Translucency. Measurement, Free -hCG and PAPP-A Poster presentation 5th
World Congress of Perinatal Medicine 23-27 September, 2001 Barcelona, Spain
37. Oktem O, Gokaslan H, Durmusoglu F, Kullu S, Kotiloglu E Multiple Cutaneous
Metastases Associated with Malignant Mixed Mullerian Tumor of the Ovary.
22
Poster presentation in the 8th Annual Meeting of the Turkish Society of
Gynecologic Oncology 1-3 May 2002 Antalya Turkiye
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