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Gen dizilimlerinin sÕnÕflandÕrÕlmasÕ, hastalÕklarÕn ön
görülebilmesi veya teúhis edilebilmesinde çok önemli
rol oynamaktadÕr. Bütün gen dizilimi üzerinde etkili
bir sÕnÕflandÕrma yapabilmek mümkün olmadÕ÷Õndan
sa÷lÕklÕ bir sÕnÕflandÕrma yapÕlabilmesi için gerekli
bilgiyi içeren genlerin özellik azaltma algoritmalarÕ
ile ayÕklanmasÕ önem taúÕmaktadÕr. Bu çalÕúmada,
özellikleri azaltmak için sezgisel arama teknikleri,
özellik azaltma yaklaúÕmlarÕ (filter, wrapper, vb.) gibi
farklÕ yöntemler analiz edilerek ön iúleme adÕmÕnÕn
daha etkin bir úekilde gerçekleútirilmesi; bunun
sonucunda elde edilen veri kümelerinin LR (Lojistik
Regresyon) ve SVM (Destek Vektör Makineleri) gibi
güçlü sÕnÕflandÕrma araçlarÕ ile daha etkin úekilde
hedeflenmiútir.
Makine
sÕnÕflandÕrÕlmasÕ
ö÷renmesinde güçlü bir sÕnÕflandÕrÕcÕ olarak kabul
edilen LR sÕnÕflandÕrÕcÕsÕ, özellik eksiltme yöntemleri
ile gen dizilimlerinin sÕnÕflandÕrÕlmasÕnda SVM kadar
geçerli ve etkin sÕnÕflama aracÕ haline gelmiútir.
$QDKWDU6|]FNOHU: Gen analizi, makine ö÷renmesi,
lojistik regresyon, özellik azaltma, SVM.
$EVUDFW
DNA microarray classification is important to
discovery of differentially expressed genes between
normal and diseased patients are a central research
problem in bioinformatics. All the genes used in the
expression profile are not informative. Further, many
of them are redundant. A pre-processing step in order
to reduce the number of genes by feature selection
and still retaining best class prediction accuracy for
the cla1ssifier is crucial for precise tumor
classification. In this study comparison between class
prediction accuracy of two different classifiers, LR
(Logistic Regression) and SVM (Support Vector
Machines), was carried out using the best genes
select by wrapper and filter technique to use heuristic
search methods. We conclude that LR together with
heuristic search based feature selection is the as
efficient as SVM to the microarray gene prediction
techniques.
.H\ZRUGV
Microarray
analysis,
binary
classification, machine learning, logistic regression,
feature reduction, tumor analysis, SVM.
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