Curriculum Vitae - School of Medicine

3/26/2015
Chu Chen, PhD
CURRICULUM VITAE
NAME:
Chu Chen
BUSINESS ADDRESS:
Neuroscience Center of Excellence, Louisiana State University Health
Sciences Center, 2020 Gravier Street, Suite D, New Orleans, LA 70112
BUSINESS PHONE:
(504)568-8458 (Office), (504)599-0918 (Lab)
BUSINESS FAX:
(504)599-0488
E-MAIL:
[email protected] [email protected]
CITIZENSHIP:
USA
EDUCATION:
9/1979 - 7/1983
Department of Biology, Nanjing University, Nanjing, P.R. China
B.S. degree in Biology
9/1983 - 7/1986
Department of Physiology, Zhejiang University School of Medicine,
Hangzhou, P.R. China, M.S. degree in Physiology
8/1989 - 12/1993
Department of Physiology, Tulane University, New Orleans, LA, USA
Ph.D. degree in Physiology
1/1994 -7/1995
Department of Otorhinolaryngology, Louisiana State University Medical
Center at New Orleans. Post-doctoral fellow
ACADEMIC, PROFESSIONAL, AND RESEARCH APPOINTMENTS:
7/2013 - Present
Professor with tenure, Neuroscience Center and Department of
Otorhinolaryngology, LSU Health Sciences Center in New Orleans
4/2013 - Present
Member, Alcohol and Drug Abuse Center of Excellence, LSU Health
Sciences Center in New Orleans
8/2012 - Present
VA’s biomedical laboratory and clinical science research and development
non-clinician intramural program member
7/2008 - 6/2013
Associate Professor with tenure, Neuroscience Center and Department of
Otorhinolaryngology, LSU Health Sciences Center in New Orleans
2/2002 – 6/2008
Tenure track Assistant Professor, Neuroscience Center and Department of
Otorhinolaryngology, LSU Health Sciences Center in New Orleans
4/1998 – 1/2002
Research Assistant Professor, Department of Otorhinolaryngology and
Neuroscience Center, Louisiana State University Health Sciences Center in
New Orleans
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Chu Chen, PhD
1998 - Present
Faculty member of Graduate School, LSU Health Sciences Center
1996 – 2001
Research Assistant Professor, Department of Otorhinolaryngology,
Louisiana State University Health Sciences Center in New Orleans
1995 - 1996
Research Instructor, Department of Otorhinolaryngology, Louisiana State
University Medical Center in New Orleans
1988 – 1989
Lecturer, Department of Physiology, Zhejiang University School of Medicine,
Hangzhou, P.R. CHINA
1986 – 1987
Instructor, Department of Physiology, Zhejiang University School of
Medicine, Hangzhou, P. R. CHINA
MEMBERSHIPS:
The Society for Neuroscience
The International Cannabinoid Research Society
The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment
HONORS, AWARDS AND FELLOWSHIPS:
The travel award for the most outstanding presentation at the 11th Annual Neuroscience Center
Retreat in Feb. 1999; LSU Medical Center in New Orleans
The travel award for the most outstanding presentation at the 7th Annual Neuroscience Center
Retreat in Feb. 1995; LSU Medical Center in New Orleans
The 1993 Excellence in Renal Research Award, the American Physiological Society
The travel award from Tulane University Graduate School in 1993
The 1992 Morris F. Shaffer and Margaret H.D. Smith-Shaffer Award for Excellence in Research,
Tulane University
Sigma XI travel award 1992; Tulane University Chapter
The Adamao-Haarstad Award for the Most Outstanding Presentation at the First GNOSN Annual
Research Forum in Nov. 1992; the Society for Neuroscience Greater New Orleans Chapter
The travel award from Tulane University Graduate School in 1991
Recipient of the Chancellor's Fellowship (1989 - 1993); Tulane University Medical Center
Outstanding Research Contributions and Academic Leadership Award, LSU Neuroscience Center,
2013
TEACHING EXPERIENCE:
2002-present
Lecture: Investigative Neuroscience 203 to PhD graduate program students
2002-present
Lecture: Molecular Neurobiology 250 to PhD graduate program students
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Chu Chen, PhD
2006-2010
Lecture: Interdisciplinary Biological system 132 to Interdisciplinary PhD graduate
program students
2004-2005
Lecture: To summer undergraduate students
1991 - 1993
Laboratory Demonstration and Assistance for Medical Physiology to Medical
Students, Department of Physiology, Tulane University School of Medicine
1988 - 1989
Lectures and Laboratory Instruction for Cardiac Physiology to Graduate students,
Department of Physiology, Zhejiang University School of Medicine
1986 - 1989
Lectures in Medical Physiology to Medical Students, Department of Physiology,
Zhejiang University School of Medicine
1983 - 1989
Laboratory Instruction for Medical Physiology to Medical Students, Department of
Physiology, Zhejiang University School of Medicine
GRADUATE STUDENT AND POST-DOC TRAINING:
3/2002-1/2003
1/2003-6/2004
2/2003-8/2005
7/2004-8/2006
1/2006-10/2008
9/2007-9/2009
7/2008-3/2009
3/2009-12/2009
8/2009-9/2011
4/2011-4/2012
8/2012-12/2013
3/2013-present
10/2013-present
Elena Werby, Ph.D., post-doc fellow
Peimin Zhu, MD, Ph.D., post-doc fellow
Xiong Zhang, MD, post-doc fellow
Nan Sang, PhD, post-doc fellow
Hongwei Yang, MD, PhD, post-doc fellow
Jian-Yi Xu, MD, PhD, post-doc fellow
Hao Sun, PhD, post-doc fellow
Huizhi Du, PhD, post-doc fellow
Rong-qing Chen, MD, post-doc fellow
Yan Wu, MD, PhD, post-doc fellow
Zhaoqian Teng, PhD, post-doc fellow
Yunping Song, PhD, post-doc fellow
Mei Hu, PhD, post-doc visiting scholar
1/2001-5/2003
5/2006-8/2009
Ali Genc, MD, MS. Graduate student in Neuroscience program
Ni Fan, MD, PhD, Graduate student in Neuroscience PhD program
Graduate student lab rotation:
Ali Genc, graduate student in the Neuroscience MS program
Daniel Navar, graduate student in Neuroscience PhD program
Michelle Steinhardt, graduate student in Neuroscience PhD program
Ni Fan, graduate student in Neuroscience PhD program
Jessica Patel, graduate student in Neuroscience PhD program
Mentoring students in Summer Undergraduate Neuroscience Program:
Ryan Date, Van Vu, Hanna Jarrell, Hongming Jin
THESIS & DISSERTATION COMMITTES:
Member of Dr. C. Leblanc PhD dissertation committee, 2000
Member of Dr. Peimin Zhu PhD dissertation committee, 2002
Chairman of Dr. Ali Genc MS thesis committee, 2003
Member of Ms. Jessica Waguespack PhD dissertation committee, 2006
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Member of Dr. Fang Liu MS thesis committee, 2006
Member of Mr. Selvakumar Selandipalayam PhD dissertation committee, 2009
Chairman of Dr. Ni Fan PhD dissertation committee, 2009
Member of Feng-Ju Weng PhD dissertation committee, Cell and Molecular Biology
program, Tulane University, 2008
Member of Ms. Sukhjeevan Grewal PhD dissertation committee, 2010
Member of Mr. Abhilash Ponnath PhD dissertation committee, 2011
Member of Dr. Hongbo He PhD dissertation committee, 2011
Member of Ms. Sophie Teng MD/PhD dissertation committee, 2014
Member of Ms. Qun Qian PhD dissertation committee, 2014
Member of Mr. Miguel F. Molina MD/PhD dissertation committee, 2014
Member of Mr. Sung-Ha Hong PhD dissertation committee, 2015
JUNIOR FACULTY MENTORING:
Scott Edwards, PhD, Assistant Professor of Physiology, LSU Health Sciences
Center
ACTIVE RESEARCH SUPPORT:
Source:
NIH-NINDS R01NS076815 (6/15/2012-3/31/2017)
Title:
Endocannabinoids in Neurodegenerative Diseases
Role on Grant: PI.
Source:
NIH-NINDS R01NS076815-02S1 (5/14/2013-3/31/2017)
Title:
Endocannabinoids in Neurodegenerative Diseases
Role on Grant: PI.
NIH/NIGMS P30GM103340 (PD: Bazan, NG) (9/01/2012-5/31/2017)
Regulation of synaptic function by miR-30b signaling in Alzheimer’s disease: Pilot
project (6/1/2014-5/31/2015)
Role on Grant: PI
Source:
Title:
PENDING RESEARCH SUPPORT:
Source:
VA 1I01BX002608-A2 (4/01/2016-3/31/2020)
Title:
Endocannabinoid metabolism in traumatic brain injury.
Role on Grant: PI.
PAST RESEARCH SUPPORT:
Source:
NIH-NIA R21AG039669
(4/01/2011-3/31/2014)
Title:
MAGL inhibition in prevention and treatment of Alzheimer’s disease
Role on Grant: PI.
Source:
NIH-NIA R21AG039669-01S1 (4/01/2011-3/31/2014)
Title:
MAGL inhibition in prevention and treatment of Alzheimer’s disease
Role on Grant: PI.
Source:
NIH-NINDS R01NS054886 (6/1/2007-11/30/2012)
Title:
Endocannabinoids in COX-2 mediated synaptic modification and neurotoxicity.
Role on Grant: PI.
Source:
NIH-NCRR P20RR16816
(2/1/2007-1/31/2013)
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Title:
Mentoring Neuroscience in Louisiana, Program Director: Dr. Nicholas, G. Bazan
Role on Grant: Mentor and co-director of two-photon imaging core facility
Source:
NIH-NINDS R01NS054886-03S1 (9/25/2009-3/31/2010)
Title:
Endocannabinoids in COX-2 mediated synaptic modification and neurotoxicity.
Role on Grant: PI.
Source:
NIH-NIDA 1R03DA025971-01 (9/15/2008-8/31/2010)
Title:
Astroglial cells in marijuana-altered synaptic plasticity
Role on Grant: PI.
Source:
Alzheimer’s Association - IIRG-05-13580 (10/01/2005-9/30/2009)
Title:
COX-2 regulation of endocannabinoid signaling in neurodegeneration.
Role on Grant: PI.
National Institute of Health NCRR P20RR16816 (2/1/2002-1/31/2007)
Mentoring Neuroscience in Louisiana, Program Director: Dr. Nicholas, G. Bazan
Project 4, Cyclooxygenases in neuronal synaptic plasticity
Role on Grant: PI:
Source:
Title:
Source:
National Science Foundation (4/1/1999-3/31/02)
Title:
Functional characterization of three P2X2 receptor splice variants
Role on Grant: Co-PI. PI: Richard Bobbin, Ph.D.
Source:
Deafness Research Foundation (1/1/1996-12/31/1997)
Title:
Nitric oxide modulation of glutamate receptor channel in spiral ganglion cells
Role on Grant: PI.
Source:
Deafness Research Foundation (1/1/1999-12/31/1999)
Title:
Expression of guinea pig P2X2 ATP receptor variants in HEK 293 cells
Role on Grant: Co-PI. PI: Margarett Parker Ph.D.
Source:
National Organization for Hearing Research (1/1/1999-12/31/1999)
Title:
Release of ATP from single cells in the organ of Corti
Role on Grant: Co-PI. PI: Richard Bobbin, Ph.D.
GRANTS PARTICIPATED:
Source:
National Institute of Health (4/01/1994- 3/31/1999)
Title:
Pharmacology of outer hair cells
Role on Grant: Post-doc fellow and research assistant professor. PI: Richard Bobbin, Ph.D.
Source:
National Institute of Health (4/01/2001- 3/31/2006)
Title:
Signaling by phospholipids and arachidonic acid in epilepsy
Role on Grant: Collaborator. PI: Nicholas, G. Bazan, M.D., Ph.D.
Source:
National Science Foundation (4/1/2001- 3/31/2004) LA EPSCoR, NSF
Title:
Micro/Nano Technologies: Neural Signaling Research
Role on Grant: Collaborator. PI: Nicholas, G. Bazan, M.D., Ph.D.
Source:
Title:
Defense Advanced Research Programs Agency (DARPA) (11/1/2001- 8/31/2003)
Identification of Synaptic Signaling Events and Behavioral Correlates in Sleep
Deprivations: Development of Novel Pharmacologic Agents
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Chu Chen, PhD
Role on Grant: Collaborator. PI: Nicholas, G. Bazan, M.D., Ph.D.
RESEARCH GRANT REVIEW:
Alzheimer’s Association grants (2004-present)
National Science Foundation Grants
Irish Health Research Board grants, Ireland (2005-2006)
Indiana University Alzheimer’s Disease Research Grants (2008-2009)
Wellcome Trust Research grants, UK (2010)
NIH NIDA Special Emphasis Panel ZDA1 - JXR – D (06) (2011)
NIH CSR Special Emphasis Panel ZRG1 MDCN-R (40) P- 2014
Medical Research Council (MRC), UK (2012)
LSU Medical School Research Enhancement Fund Grants (2010-2012)
The LSUHSC Alcohol and Drug Abuse Center of Excellence (ADACE) Pilot Grants (2014)
Florida State the Ed and Ethel Moore Alzheimer’s Disease Research Program Review Panel
INVITED PRESENTATIONS:
Tulane University School of Medicine, May 1993
Tulane University School of Medicine, Department of Physiology, June 1993
University of Washington at Seattle, Department of Physiology and Biophysics; June 1993.
Texas Tech University at Lubbock, Department of Physiology; July, 1993
Emory University School of Medicine, Department of Anatomy and Cell Biology; October,
1994
Indiana University School of Medicine, Department of Physiology, December, 1994
Medical University of South Carolina, Department of Pathology and Laboratory Medicine; May,
1998
Louisiana State University, College of Basic Science, Department of Biological Science, April, 1999
Tulane University School of Medicine, Department of Physiology, September, 2002
Tulane University, Department of Cellular and Molecular Biology, September, 2006
Louisville University School of Medicine, Department of Anatomical Sciences and Neurobiology,
November, 2006
Tulane University, Department of Cellular and Molecular Biology, February, 2007
Ohio State University Biomedical School, Department of Pharmacology, May, 2008
Albany Medical College, Center for Neuroscience and Neuropharmacology, September, 2008
Tulane University School of Medicine, Department of Physiology, November, 2008
University of North Texas, Department of Pharmacology and Neuroscience, February, 2009
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Chu Chen, PhD
Tulane University School of Medicine, Department of Pharmacology, March, 2010
Shanxi University, College of Environment and Resources, China, November, 2010
Nanjing Medical University, Department of Neurobiology, China, November, 2010
Nanjing University School of Medicine, November, China, 2010
Zhejiang University School of Medicine, China, November, 2010
Zhejiang University School of Medicine, the First Affiliated Hospital, China, November, 2010
Zhejiang Academy of Medical Sciences, Institute of Material Medica, China, November, 2010
Zhejiang University School of Medicine, the First Affiliated Hospital, China, April, 2011
Louisiana State University Health Sciences Center, Department of Physiology, October, 2011
Shanxi University, College of Environment and Resources, China, April, 2012
Huazhong University of Science and Technology, School of Medicine, China, April, 2012
University of Kentucky, Sanders-Brown Center on Aging, August, 2012
University of Huston, Center for Nuclear Receptors and Signaling, January, 2013
University of Pittsburgh School of Medicine, Pittsburgh Institute for Neurodegenerative Diseases,
January, 2013
Georgia Regents University, Department of Physiology, February, 2013
University of University of Central Florida, the Burnett School of Biomedical Sciences, March, 2013
Virginia Commonwealth University School of Medicine, Department of Anatomy and Neurobiology,
August, 2013
Shanxi University, College of Environment and Resources, China, October, 2013
Baylor College of Medicine, the Huffington Center on aging, October, 2013
University of North Texas, Department of Pharmacology and Neuroscience, January, 2014
Southeast University, Institute of life sciences, China, July, 2014
Guangzhou Medical University, Guangzhou Brain Hospital, China, November, 2014
EDITORAL ACTIVITY AND JOURNAL REVIEW:
Alzheimer's Disease Research Journal
American Journal of Physiology
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British Journal of Pharmacology
Brain Research Bulletin
Cell Death & Differentiation
Cell Death & Disease
Cellular Physiology and Biochemistry
Cellular and Molecular Life Science
Cellular and Molecular Neurobiology
Chemical Research in Toxicology
Chemosphere
CNS Neuroscience & Therapeutics
Drug Design, Development and Therapy
Ecotoxicology and Environmental Safety
Environmental Toxicology
European Journal of Neuroscience
European Journal of Pharmacology
Experimental Neurology
Gene Regulation and Systems Biology
Glia
Journal of Alzheimer's Disease
Journal of Biochemistry
Journal of Neurochemistry
Journal of Neuroinflammation
Journal of Neuro-Oncology
Journal of the Neurological Sciences
Journal of Neurophysiology
Journal of Neuroscience
Journal of Neuroscience Research
Journal of Pharmacological Sciences
Journal of Pharmacology and Experimental Therapeutics
Journal of Physiology (Lond)
Journal of Psychiatric Research
Medical Science Monitor
Methods and Findings in Experimental and Clinical Pharmacology
Molecular Neurobiology
Neurobiology of Aging
Neurobiology of Disease
Neurochemical Research
Neuropharmacology
Neuroscience
Neuroscience Letters
NeuroSignals
Nature Chemical Biology
Proceedings of the National Academy of Sciences of the United States of America
Psychopharmacology
SLEEP
Toxicological Sciences
Editorial board: Journal of Parkinson's diseases and Alzheimer's diseases
INSTITUTIONAL PROFESSIONAL SERVICES:
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Served as a judge for the Graduate School Research Day, 2002; 2003, 2005, 2009, 2012
Served as a judge for the Travel award committee of Neuroscience Retreat (2003-)
Member of Neuroscience Graduate Program Advisory Committee (2004-present)
Coordinator of Neuroscience Center Seminar (2006-2013)
The Research Enhancement Fund Committee, LSU School of Medicine (2010-2012)
Member of Inter-departmental Promotions and Tenure Committee, LSU School of Medicine (20092013)
Member of Anatomy and Cell Biology Department Promotions and Tenure Committee (2012)
Promotion and Tenure Committee, Neuroscience Center (2013)
Member of Promotion and Tenure Committee, Department of Otorhinolaryngology (2014)
PUBLICATIONS:
1. Zhang J, Teng Z, Song Y, Hu M & Chen C. (2015) Inhibition of monoacylglycerol lipase prevents
chronic traumatic encephalopathy-like neuropathology in a mouse model of repetitive mild closed
head injury. Journal of Cerebral Blood Flow & Metabolism 35: 443-453.
2. Xu J & Chen C. (2015) Endocannabinoids in synaptic plasticity and neuroprotection.
Neuroscientist 21: 152-168.
3. Zhang J, Hu M, Teng Z, Tang Y & Chen C. (2014) Synaptic and cognitive improvements by
inhibition of 2-AG metabolism are through upregulation of microRNA-188-3p in a mouse model of
Alzheimer’s disease. Journal of Neuroscience 34:14919-14933. (Featured article)
Editor's Commentary: http://www.jneurosci.org/content/34/45/i.full. Highlighted in Nature ScienceBusiness eXchange: http://www.nature.com/scibx/journal/v7/n46/full/scibx.2014.1354.html
4. Chen R, Zhang J, Fan N, Teng Z, Wu Y, Yang H, Tang Y, Sun H, Song Y & Chen C. (2013) ∆9THC-caused synaptic and memory impairments are mediated through COX-2 signaling. Cell
155:1154-1165.
(Featured and highlighted in Cell : http://www.elsevier.com/connect/preventing-marijuana-inducedmemory-problems-with-OTC-painkillers,
Science:
http://news.sciencemag.org/brainbehavior/2013/11/painkillers-may-curb-memory-loss-medical-marijuana, Science Signaling:
(http://stke.sciencemag.org/cgi/content/abstract/6/304/ec291),
Nature:
(http://www.nature.com/nature/journal/v503/n7477/full/503440b.html),
Nature Reviews
Neuroscience: (http://www.nature.com/nrn/journal/v15/n1/full/nrn3659.html), and covered by
various news media.
5. Chen R, Zhang J, Wu Y, Wang D, Feng G, Tang YP, Teng Z & Chen C. (2012) Monoacylglycerol
lipase is a therapeutic target for Alzheimer’s disease. Cell Reports 2:1329-1339 (Covered by
various news media).
6. Pan W, Hsuchou H, Jayaram B, Khan RS, Huang EY, Wu X, Chen C & Kastin AJ. (2012) Leptin
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Chu Chen, PhD
action on nonneuronal cells in the CNS: potential clinical applications. Annals of the New York
Academy of Sciences 1264:64-71.
7. He H, Mahnke A, Doyle S, Fan N, Wang C, Hall B, Tang YP, Inglis F, Chen C & Erickson JD (2012)
Neurodevelopmental role for VGLUT2 in pyramidal neuron plasticity, dendritic refinement, and in
spatial learning. Journal of Neuroscience 32:15886-15901.
8. Xu J, Zhang J & Chen C. (2012) Long-lasting potentiation of hippocampal synaptic transmission by
direct cortical input is mediated via endocannabinoids. Journal of Physiology (Lond) 590:23052315.
9. Du H, Chen X, Zhang J & Chen C. (2011) Inhibition of COX-2 expression by endocannabinoid 2arachidonoylglycerol is mediated by PPAR-. British Journal of Pharmacology 163:1533-1549.
10. Chen X, Zhang J & Chen C. (2011) Endocannabinoid 2-arachidonoylglycerol protects neurons
against -amyloid insults. Neuroscience 178:159-168.
11. Yu T, Li Z, Jia Z, Clapcote SJ, Liu C, Li S, Asrar S, Pao A, Chen R, Fan N, Carattini-Rivera S,
Bechard AR, Spring S, Henkelman RM, Stoica G, Matsui S-I, Nowak NJ, Roder JC, Chen C,
Bradley A & Yu YE. (2010) A mouse model of Down Syndrome trisomic for all human
chromosome 21 syntenic regions. Human Molecular Genetics 19:2780–2791.
13. Yu T, Liu C, Belichenko P, Clapcote SJ, Li S, Pao A, Kleschevnikov A, Bechard AR, Asrar S, Chen
R, Fan N, Zhou Z, Jia Z, Chen C, Roder JC, Liu B, Baldini A, Mobley WC &Yu YE. (2010) Effects of
individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal longterm potentiation and cognitive behaviors in mice. Brain Research 1366:162-171.
14. Chen C. (2010) COX-2’s new role in inflammation. Nature Chemical Biology 6: 401-402.
15. Xu J, Chen R, Zhang J & Chen C. (2010) Endocannabinoids differentially modulate synaptic
plasticity in rat hippocampal CA1 pyramidal neurons. PLoS ONE 5:e10306.
16. Sang N, Zhang J & Chen C (2010) Anandamide potentiation of miniature spontaneous excitatory
synaptic transmission is mediated via IP3 pathway. Neurochemistry International 56:590-596.
17. Fan N, Yang H, Zhang J & Chen C. (2010) Reduced expression of glutamate receptors and
phosphorylation of CREB are responsible for ∆9-THC-impaired hippocampal synaptic plasticity.
Journal of Neurochemistry 112:691-702.
18. Zhang X, Zhang J & Chen C. (2009) Long-term potentiation at hippocampal perforant path-dentate
astrocyte synapses. Biochemical and Biophysical Research Communication 383:326-330.
19. Yang H, Zhang J, Breyer RM & Chen C. (2009) Altered hippocampal long-term synaptic plasticity in
mice deficient in the PGE2 EP2 receptor. Journal of Neurochemistry 108:295-304.
20. Grewal S, Defamie N, Zhang X, Gois SD, Shawki A, Mackenzie B, Chen C, Varoqui H & Erickson
JD. (2009) SNAT2 amino-acid transporter is regulated by osmolytes of the SLC6 GABA transporter
subfamily and may play no role in delivering glutamine for spontaneous glutamatergic transmission.
Journal of Biological Chemistry 284:11224-11236.
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21. Zhang J & Chen C. (2008) Endocannabinoid 2-arachidonoylglycerol protects neurons by limiting
COX-2 elevation. Journal of Biological Chemistry 283: 22601–22611.
22. Yang H & Chen C. (2008) COX-2 in synaptic signaling. Current Pharmaceutical Design 14:
1443-1451.
23. Yang H, Zhang J, Andreasson K & Chen C. (2008) COX-2 Oxidative metabolism of
endocannabinoids augments hippocampal synaptic plasticity.
Molecular and Cellular
Neuroscience 37: 682-695.
24. Sang N, Zhang J & Chen C (2007) COX-2 oxidative metabolite of endocannabinoid 2-AG
enhances excitatory glutamatergic synaptic transmission and induces neurotoxicity. Journal of
Neurochemistry 102: 1966-1977.
25. Cui J, Zhang X, Zhao Y, Chen C & Bazan N. (2006) Allodynia and hyperalgesia suppression by a
novel analgesic in experimental neuropathic pain. Biochemical and Biophysical Research
Communication 350: 358-363.
26. Sang N & Chen C. (2006) Lipid signaling and synaptic plasticity. Neuroscientist 12: 425-434.
27. Sang N, Zhang J & Chen C. (2006) PGE2 glycerol ester, a COX-2 oxidative metabolite of 2arachidonoyl glycerol, modulates inhibitory synaptic transmission in mouse hippocampal neurons.
Journal of Physiology (Lond) 572: 735-745.
28. Chen C, Hardy M, Zhang J, LaHoste GJ & Bazan NG. (2006) Altered NMDA receptor trafficking
contributes to sleep deprivation-induced hippocampal synaptic and cognitive impairments.
Biochemical and Biophysical Research Communication 340: 435-440.
29. Chen C. (2005) β-Amyloid increases dendritic Ca2+ influx by inhibiting the A-type K+ current in
hippocampal CA1 pyramidal neurons. Biochemical and Biophysical Research Communication
338: 1913-1919.
30. Sang N, Zhang J, Marcheselli V, Bazan NG & Chen C. (2005) Postsynaptically synathsized PGE2
modulates hippocampal synaptic transmission via a presynaptic PGE2 EP2 receptor.
Journal of Neuroscience 25: 9858-9870.
31. Chen C & Bazan, NG. (2005) Lipid Signaling: Sleep, Synaptic Plasticity, and Neuroprotection.
Journal of Prostaglandins & Lipid Mediators 77: 65-76. (Invited and peer reviewed review
article)
32. Gois SD, Schafer MK-H, Defamie N, Chen C, Ricci A, Weihe E, Varoqui H & Erickson JD. (2005)
Homeostatic scaling of vesicular glutamate and GABA transporters expression in rat neocortical
circuits. Journal of Neuroscience 25: 7121-7133.
33. Chen C & Bazan NG. (2005) Endogenous PGE2 regulates membrane excitability and synaptic
transmission in rat hippocampal CA1 pyramidal neurons. Journal of Neurophysiology 93: 929941.
34. Zhu P, Genc A, Zhang X, Zhang J, Bazan NG & Chen, C. (2005) Heterogeneous expression and
regulation of PGE2 receptors in the hippocampus. Journal of Neuroscience Research 81: 817-
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826.
35. Chen C. (2004) ZD7288 inhibits postsynaptic glutamate receptor-mediated responses at
hippocampal perforant path-granule cells synapses. European Journal of Neuroscience 19: 643649.
36. McDermott CM, LaHoste GL, Chen C, Musto A, Bazan NG & Magee JC. (2003) Sleep deprivation
causes behavioral, synaptic and membrane excitability alterations in hippocampal neurons.
Journal of Neuroscience 23: 9687-9695.
37. Chen C & Bazan NG. (2003) Acetaminophen modifies hippocampal synaptic plasticity via a
presynaptic 5-HT2 receptor. NeuroReport 14: 743-747.
38. Chen C, Magee JC & Bazan NG. (2002) Cyclooxygenase-2 regulates prostaglandin E2 signaling in
hippocampal long-term synaptic plasticity. Journal of Neurophysiology 87: 2851-2857.
39 Rodriguez de Turco EBR, Tang W, Topham MK, Sakane F, Marcheselli VL, Chen C, Taketomi A,
Prescott S & Bazan NG. (2001) Diacylglcerol kinase epsilon regulates suizure susceptibility and
long-term potentiation through arachidonoyl-inositol lipid signaling. Proceedings of National
Academy of Science USA 98: 4740-4745.
40 Chen C, Magee JC, Marcheselli V, Hardy M & Bazan NG. (2001) Attenuated long-term potentiation
in hippocampal dentate gyrus neurons of mice deficient in the PAF receptor.
Neurophysiology 85: 384-390.
Journal of
41 Chen C, Barnes AP, Parker MS, Deininger PL & Bobbin RP. (2000) Functional expression of three
P2X2 receptor splice variants from guinea pig cochlea. Journal of Neurophysiology 83: 1502 1509.
42 Chen C & Bazan NG. (1999) Platelet-activating factor inhibits ionotropic GABA receptor activity in
cultured hippocampal neurons. NeuroReport 10: 1-5.
43 Ruel J*, Chen C*, Pujol R, Bobbin R & Puel JL. (1999) AMPA-preferring glutamate receptors in
cochlear physiology of adult guinea pig. Journal of Physiology (Lond) 518: 667-680.
*J. Ruel and C. Chen contributed equally to this work
44 Chen C & Bobbin RP. (1998) P2X receptors in cochlear Deiters’ cells. British Journal of
Pharmacology 124: 337-344.
45 Nenov AP, Chen C & Bobbin RP. (1998). Outward rectifying potassium currents are the dominant
voltage activated currents present in Deiters’ cells. Hearing Research 123, 168-182.
46 Chen C, Skellett RA, Fallon M, & Bobbin RP. (1997). Additional pharmacological evidence that
endogenous ATP modulates cochlear mechanics. Hearing Research 118: 47-61.
47 Skellett RA, Chen C, Fallon M, Nenov AP & Bobbin RP. (1 997). Pharmacological evidence that
endogenous ATP modulates cochlear mechanics. Hearing Research 111:42-54.
48 Chen C. (1997). Hyperpolarization-activated current (Ih) in primary auditory neurons. Hearing
Research 110: 179-190.
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Chu Chen, PhD
49 Chen C, Leblanc C & Bobbin RP. (1997). Differences in the distribution of responses to ATP and
acetylcholine between outer hair cells of rat and guinea pig. Hearing Research 110: 87-94.
50 Chen C, Leblanc C & Bobbin RP. (1996). Differences in the cholinergic receptor on outer hair cells
of rat and guinea pig. Hearing Research 98: 9-17.
51 Chen C, Nenov AP & Bobbin RP. (1995). Noise exposure alters the response of outer hair cells to
ATP. Hearing Research 88: 215-221.
52 Chen C, Nenov AP, Skellett R, Fallon M, Bright L, Norris CH & Bobbin RP. (1995). Nitroprusside
suppresses cochlear potentials and outer hair cell responses. Hearing Research 87: 1-8.
53 Chen C, Nenov AP, Norris CH & Bobbin RP. (1995). ATP modulation of L-type Ca2+ channel
currents in guinea pig outer hair cells. Hearing Research 86:25-33.
54 Chen C & Schofield GG. (1995). NO donors enhanced calcium currents and blocked noradrenalineinduced calcium current inhibition in rat sympathetic neurons. Journal of Physiology (Lond)
482:521-531.
55 Chen C & Schofield GG. (1993). Nitric oxide modulates calcium channel currents in rat sympathetic
neurons. European Journal of Pharmacology 243: 83-86.
56 Chen C & Schofield GG. (1993). Differential neuromodulation of calcium currents by norepinephrine
in sympathetic neurons. Journal of Neurophysiology 70: 1440-1450.
57 Chen C & Schofield GG. (1992). Ca2+ currents of fast blue labeled superior cervical ganglion
neurons. Journal of Neuroscience Methods 45: 63-69.
58 Chen C, Mitchell KD & Navar LG. (1992). Role of endothelium-derived nitric oxide (EDNO) in the
renal hemodynamic response to amino acid infusion. American Journal of Physiology 263:
R510-R516.
59 Chen C, Hu HC, Chen GX & Hsu HC. (1991). Effects of cimetidine on transmembrane potential in
normal and hypoxic papillary muscle cells of guinea pig heart. Journal of Zhejiang Medical
University 20(3):104-106.
60 Hu HC, Chen C, Chen GX & Hsu HC. (1989). Measurement of characteristic parameters of ECG
and computerized diagnosis of malignant arrhythmia. Journal of Zhejiang Medical University 19:
101-104.
61 Chen C. (1989). The progress in measurements of intracellular free calcium activity in myocardium.
Chinese Journal of Pathophysiology 5(2): 244-246.
62 Chen C, Hu HC, Chen GX & Hsu HC. (1989). Histamine induced delayed afterdepolarization and
triggered activity of guinea pig papillary muscle. Journal of Zhejiang Medical University 18(6):
241-243.
63 Chen C. (1989). Electrophysiological properties of pancreatic beta-cells.
Physiological Science 20: 268-270.
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Chu Chen, PhD
64 Chen C, Chen GX & Hsu HC. (1989). Effect of calcium concentration on the ventricular fibrillation
threshold and its relation to the levels of cAMP, cGMP and ATP in rat ischemic heart. Chinese
Journal of Pathophysiology 5: 134-138.
65 Chen C. (1989). Histamine and Cardiac arrhythmia. Journal of Zhejiang Medical University
19(1): 37-42.
66 Chen C. (1988). The role of oxygen free radicals in myocardial injury. Journal of Zhejiang
Medical University 17(1): 37-40.
67 Chen C, Chen GX & Hsu HC. (1987). Effect of magnesium on ventricular vulnerability to fibrillation
in normal and regional ischemic isolated rat heart. Journal of Electrocardiology 6: 54-57.
68 Chen C. (1987). Calcium and ventricular fibrillation. Journal of Zhejiang Medical University
16(5): 229-232.
69 Chen C, Chen GX & Hsu HC. (1986). Effects of phentolamine, propranolol, verapamil and low
extracellular calcium on reperfusion-induced ventricular fibrillation in the isolated guinea pig heart.
Journal of Electrocardiology 5: 246-249.
70 Wu S, Chen C, Chen GX & Hsu HC. (1985). Effect of glucose on the threshold of ventricular
fibrillation induced by altered calcium concentration in rat. Journal of Zhejiang Medical
University 14: 257-260.
71 Chen J, Wang JJ, Chen C & Wang M. (1985). An electrophysiological observation of the fiber
connections between paraventricular nucleus of the hypothalamus and solitary tract nucleus and
between paraventricular nucleus and periaqueductal gray. Chinese Science Bulletin 30: 955959.
SCIENTIFIC PRESENTATION & ABSTRACTS:
1. Chen, C., Chen, G.X. and Hsu, H.C. (1987). Effect of calcium concentration on the ventricular
fibrillation threshold and its relation to the levels of cAMP, cGMP and ATP in rat ischemic heart. J.
Mol. Cell. Cardiol. 19 (suppl iv):s69.
2. Chen, C., Hu, H.C., Chen, G.X. and Hsu, H.C. (1989). Electrophysiological actions of cimetidine on
delayed after-depolarization and triggered activity induced by histamine in papillary muscle of
guinea pig heart. Chines Physiol. Soci. News Communi. (Suppl):168.
3. Hu, H.C., Chen, C., Jin, C.X., Chen, G.X. and Hsu, H.C. (1989). Differences of ventricular
fibrillation threshold in pacing and sinus rhythmic hearts determined by automatic measuring
system of VFT. J. Mol. Cell. Cardiol. 21(suppl II):s26.
4. Chen, C., Mitchell, K.D. and Navar, L.G. (1991). Role of endothelium-derived nitric oxide (EDNO)
in the renal hemodynamic response to amino acid infusion. FASEB J. 5:A397.
5. Chen, C. and Schofield, G.G. (1992). Ca2+ currents of fast blue labeled superior cervical ganglion
neurons. FASEB J. 6:A248 and Biophysical J. 61:A248.
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Chu Chen, PhD
6. Chen, C. and Schofield, G.G. (1992). Heterogeneity of calcium channels of different rat
sympathetic neurons. Society for Neurosci. Abstr. 18:430.
7. Chen, C. and Schofield, G.G. (1993). Calcium currents of renal efferent sympathetic neurons from
spontaneously hypertensive rats. FASEB J. 7:A186.
8. Chen, C. and Schofield, G.G. (1993). Nitric oxide modulates calcium currents of superior cervical
ganglion neurons. Society for Neurosci. Abstr. 19:1129.
9. Chen, C. and Schofield, G.G. (1994). Neuromodulation of calcium currents is altered in superior
cervical ganglion neurons of spontaneously hypertensive rat. Biophysical J. 66:A432.
10. Chen, C., Nenov, A.P., Norris, C.H., Kujawa, S.G. and Bobbin, R.P. (1994). Nitric oxide may be
involved in the cochlear amplifier. XXXIst Workshop on Inner Ear Biology, Montpellier, France.
Abstract:47.
11. Chen, C., Norris, C.H. and Bobbin, R.P. (1995). Acetylcholine inhibits L-type calcium channel
currents in outer hair cells via a nicotinic-like receptor.
18th ARO Abstr. 642.
12. Chen, C., Leblanc, C. and Bobbin, R.P. (1995). Pharmacological differences in the cholinergic
receptor on outer hair cells of rat and guinea pig. Society for Neurosci. Abstr. 21:2138.
13. Chen, C., Leblanc, C. and Bobbin, R.P. (1996). ATP does not generate a current response in outer
hair cells of rat cochlea. 19th ARO Abstr.
14. Chen, C. (1996). Hyperpolarization-activated current in guinea pig spiral ganglion cells. Society
for Neurosci. Abstr.22: 423
15. Athas, G.B., Chen, C., Bobbin, R.P. and Garcia, M.M. (1997). Nicotinic acetylcholine receptor
subunits in outer hair cells of the guinea pig cochlea demonstrated by expression profiling. 20th
ARO Abstr: 57.
16. Nenov, A. P., Chen, C., Norris, C.H. and Bobbin, R.P. (1997) Voltage dependent currents in deiters'
cells from guinea pig cochlea. 20th ARO Abstr
17. Chen, C. and Bobbin, R.P. (1997) Acetylcholine potentiation of glutamate-induced response in
guinea pig spiral ganglion cells. 20th ARO Abstr: 600.
18. Bobbin, R.P., Chen, C., Skellett, R.A. and Fallon, M. (1997). The ATP antagonist, suramin,
prevents the time related decrease of the quadratic (f2-f1) otoacoustic distortion product. 20th
ARO Abstr: 54.
19. Chen, C. and Bobbin, R.P. (1997) Differences in effects of purinergic antagonists on P2X receptor
in the cochlea. Society for Neurosci. Abstr: 23:1782.
20. Chen, C. and Bobbin, R.P. (1998) Glutamatergic receptors in spiral ganglion neurons are
predominantly AMPA-preferring. 21th ARO Abstr:88
20. Bobbin, R.P., Chen, C., Skellett, R. and Fallon, M. (1998) Pharmacological evidence that ATP
modulates cochlear mechanics. 21th ARO Abstr:246.
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Chu Chen, PhD
21. Chen, C., DeCoster, M., Magee, J., Bobbin, R.P. and Bazan, N.G. (1998) Platelet-activating factor
modulates γ-aminobutyric acid (GABAA ) receptor responses in cultured hippocampal neurons.
Sixth International Congress on platelet-activating factor and related lipid mediators. New Orleans,
USA.
22. Chen C., Barnes, A.P., Parker, M.S., Deininger, P.L. and Bobbin, R.P. (1999) Functional
expression of guinea pig cochlear P2X2 ATP receptor variants in HEK 293 cells. 22th ARO Abstr:
23. Chen, C., DeCoster, M., Magee, J., Bobbin, R.P. and Bazan, N.G. (1999) PAF decreases
postsynaptic ionotropic GABA receptor activity in hippocampal neurons. J. Neurochem. 72 :S74c
24. Chen, C. Magee, J. C., Marcheselli, V., Hardy, M. and Bazan, N.G. (2000) Long-term potentiation
is attenuated in hippocampal dentate gyrus neurons of mice deficient in the platelet-activating factor
receptor. Society for Neurosci. Abstr
25. Chen, C. Magee, J. C. and Bazan, N.G. (2001) COX-2 regulates membrane excitability and
synaptic plasticity in hippocampal dentate granule neurons. Society for Neurosci. Abstr
26. Chen, C. and Bazan, N.G. (2002) 5-HT2 receptors mediate SCP-1-induced synaptic modification in
hippocampal perforant path dentate granule cell synapses. Society for Neurosci. Abstr.
27. Genc, A., Zhu, P., Bazan, N.G. & Chen, C. (2003) Profile of prostaglandin E2 receptors in rodent
hippocampus and cortex. Society for Neurosci. Abstr
28. Chen, C. (2003) Ih channels do not participate in synaptic transmission and plasticity at
hippocampal perforant path-granule cell synapses. Society for Neurosci. Abstr
29. Zhang, X., Bazan, N.G. & Chen, C. (2003) SCP-1 inhibits voltage-gated calcium channel currents
in rat dorsal root ganglion neurons. Society for Neurosci. Abstr
30. Zhu P, Genc A, Zhang X, Bazan NG, Chen C. (2004) PGE2 receptors expression and regulation
in the hippocampus. Society for Neurosci. Abstr
31. C. Chen, N.G. Bazan. (2004) Endogenous PGE2 regulates membrane excitability and synaptic
transmission in hippocampal ca1 pyramidal neurons. Society for Neurosci. Abstr
32. Zhang X, Zhang J & Chen C. (2005) Long Term Potentiation in Hippocampal Dentate Gyrus
Astrocytes. Society for Neurosci. Abstr
33. Sang N, Zhang J, Bazan NG & Chen C. (2005) Prostaglandin E2 functions as a retrograde
messenger in hippocampal synaptic transmission. Society for Neurosci. Abstr
34. Sang N, Zhang J & Chen C. (2006) PGE2-G enhances hippocampal excitatory synaptic release
and induces neurotoxicity. Society for Neurosci. Abstr
35. Yang H, Zhang J, Andreasson K & Chen C. (2007) COX-2 Oxidative Metabolism of
Endocannabinoids Augments Hippocampal Synaptic Plasticity. Society for Neurosci. Abstr
36. Zhang J & Chen C (2008) Endocannabinoid 2-AG protects neurons by limiting COX-2elevation.
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Chu Chen, PhD
8th Biennial Meeting of APSN, Shanghai, June, 2008. J Neurochem 106 (Suppl 1):P49, 2008
37. Yang H, Zhang J, Breyer RM & Chen C. (2008) Hippocampal Long-Term Potentiation Is Impaired in
Mice Deficient in the EP2 Receptor. Society for Neurosci. Abstr
38. Xu J-Y, Zhang J & Chen C. (2009) Long-term depression of glutamatergic synaptic
transmission is differentially modulated by endocannabinoids in hippocampal CA1 pyramidal
neurons. Gordon Research Conferences on cannabinoid function in the CNS, University of
New England, Biddeford, ME, August 2-7, 2009
39. Xu J-Y, Zhang J & Chen C. (2009) Endocannabinoids differentially modulates synaptic plasticity in
hippocampal CA1 pyramidal neurons. Society for Neurosci. Abstr Chicago, October 17-21
40. Chen X, Zhang J & Chen C. (2010) Endocannabinoid 2-arachidonoylglycerol protects neurons from
beta-amyloid insults. The 2010 International Conference on Alzheimer's Disease (ICAD), Honolulu,
Hawaii, USA, July 10-15, 2010
41. Chen C, Du H, Chen X & Zhang J (2011) PPAR- mediates 2-arachidonoylglycerol-induced
suppression of COX-2 expression. The 21st Annual Symposium of the International Cannabinoid
Research Society, St. Charles, Illinois USA, July 5-10, 2011
42. Xu J, Zhang J & Chen C. (2012) Long-lasting potentiation of hippocampal synaptic transmission by
direct cortical input is mediated via endocannabinoids. The 2012 International Symposium on
Synaptic Transmission and Plasticity, Chongqing, China, April 26-28, 2012
43. Rongqing Chen, Jian Zhang1, Yan Wu, Dongqing Wang, Guoping Feng, Ya-Ping Tang and Chu
Chen (2012) Monoacylglycerol lipase contributes to pathogenesis of Alzheimer’s disease. The
Alzheimer's Association International Conference 2012 (AAIC), Vancouver, British Columbia,
Canada, July 14-19, 2012
44. Chen C, Zhang J, and Teng Z. (2013) Synaptic and cognitive improvements by inhibition of
monoacylglycerol lipase are through upregulation of the miRNA targeting BACE1 in Alzheimer’s
disease. Society for Neurosci. Abstr San Diego, November 9-13
45. Chen C, Zhang J, and Teng Z. (2013) Synaptic and cognitive improvements by inhibition of
monoacylglycerol lipase are through upregulation of the miRNA targeting BACE1 in Alzheimer’s
disease. RNA Metabolism in Neurological Disease meeting Abstr San Diego, November 7-8
46. Chen C. (2014) Regulation of the miRNA targeting β-secretase by endocannabinoid signaling in
Alzheimer’s disease. The 2014 International Symposium on Synaptic Transmission and Plasticity,
Wuhan, China, June 26-30, 2014
47. Chen C. (2015) Alleviation of Alzheimer’s disease neuropathology by inhibition of monoacylglycerol
lipase is through upregulation of miR-188-3p that targets BACE1. Neuroepigenetics, Santa Fe, New
Mexico, February 22—26, 2015
BOOK CHAPTERS:
1. Zhang J and Chen C. (2015) ∆9-THC and COX-2 signaling. In Victor R Preedy (Ed), The
Comprehensive Handbook of Cannabis Related Pathology. Elsevier Publisher, Amsterdam,
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Chu Chen, PhD
Netherlands, pp. (In press)
2. Bobbin, R.P., Barnes, A.P., Chen, C., Deininger, P.L., LeBlanc, C.S. and Parker, M.S. (2000)
Transmitters in the cochlea: ATP as a neuromodulator in the organ of Corti. In C. I. Berlin and
B.J.B. Keats (Ed.), Genetics and Hearing Loss, Singular Publ., San Diego, CA. pp: 87-110.
3. Bobbin, R.P., Chen, C., Nenov, A.P. and Skellett, R.A. (1998) Transmitters in the Cochlea: The
quadratic distortion product and its time varying response may reflect the function of ATP in the
cochlea. In C. I. Berlin (Ed.), Otoacoustic Emissions, Singular Publ., San Diego, CA. pp:61-84.
PATENTS:
1. U.S. Provisional Patent Application No. 61/897,344: Compositions, Methods of use, and methods of
treatment. (Filed on October, 2014)
2. U.S. Provisional Patent Application No. 62/069,910: Methods and compositions to treat Alzheimer’s
disease. (Filed on October, 2014)
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