CURRICULUM VITAE - School of Medicine

Curriculum vitae
Mert Erkan, M.D., Associate Professor of Surgery
h-Index (as of June 2014): 20
Languages
English, German, Turkish
Qualifications
September 1995
Medical Doctor, University of Istanbul, Istanbul, Turkey
March 2001
Qualified Surgeon, Thesis: Retrospective analysis of 177 patients treated due
to iatrogenic biliary injury. University of Istanbul, Istanbul, Turkey,
December 2007
nd
2
Doctaral degree, “summa cum laude”,
Thesis: The influence of tumor
modulated microenvironment on pancreatic cancer behavior. University of
Heidelberg
August 2010
Abdominal Surgeon / Speciality in Digestive Surgery, Klinikum r.d. Isar,
Technische Universität München / Bayerische Landesärstekammer (Chamber
of medicine of Bavaria)
December 2011
Associate Professor of Surgery, Chirurgische Klinik, Klinikum r.d.Isar,
Technische Universität München, Munich, Germany
Professional Appointments
10/1995 – 08/2000
Surgical resident. Department of Surgery, Istanbul Faculty of Medicine,
University of Istanbul, Istanbul, Turkey
02/1998
Visiting Surgeon. Cleveland Clinic Florida, Fort Lauderdale, Florida, USA
03/2001 – 04/2002
Consultant Surgeon (Hepato-Pancreato-Biliary Surgery Unit) Department of
Surgery, Istabul Faculty of Medicine, University of Istanbul, Istanbul, Turkey
06/2002 – 08/2002
Training in endoscopy. Surgical Endoscopy Unit. Department of Surgery,
Istabul Faculty of Medicine, University of Istanbul, Istanbul, Turkey
07/2003
Visiting
Surgeon.
Department
of
Surgery,
University
of
Heidelberg,
Heidelberg, Germany
10/2003 – 06/2007
Post doctoral research fellow in the European Molecular Biology Laboratory.
Department of Surgery, University of Heidelberg, Heidelberg, Germany
07- 10/2007
Post doctoral research fellow. Department of Surgery, Klinikum r.d.Isar,
Technische Universität München, Munich, Germany
10/2007 – 08/2010
Surgical resident, Department of Surgery, Klinikum r.d.Isar, Technische
Universität München, Munich, Germany
08/2010
Qualified Abdominal Surgeon (Medical Board of Bavaria) Department of
Surgery, Klinikum r.d.Isar, Technische Universität München, Munich, Germany
1
01/2011
Consultant Surgeon, Department of Surgery, Klinikum r.d.Isar, Technische
Universität München, Munich, Germany
03/2013 – 03/2014
Head of Pancreatic Surgery, Department of Surgery, Klinikum r.d.Isar,
Technische Universität München, Munich, Germany
06/2014 -
Associate Professor of Surgery, Koc University School of Medicine, Istanbul,
Turkey
Grants
2008
BMBF: NGFNplus. Subproject: Cancer specific activation of stroma. Project number:
01GS08115. Dr. J. Kleeff, Dr. M. Erkan, Dr. C.W. Michalski, Dr. H. Friess.
€509.250
2010
DFG: International scientific organisation: Dr. M. Erkan: “Pancreatic star alliance:
Consensus criteria on PSC – StellaTUM-“, München 30.01.2011 – 01.02.2011. GZ: ER
563/3-1, AOBJ: 577801.
€ 11.330
Else-Kröner-Fresenius
Stiftung:
Molecular
mechanisms
of
cannabinoid-
mediated tumor-stroma interactions in pancreatic cancer: Dr. CW Michalski, Dr. M
Erkan, Prof. I. Esposito, Prof. J. Kleeff,
€300.000
2011
KKF: Kommission für Klinische Forschung TUM: Stellate cells as antigen presenting
cells of the pancreas: Characterization of class II MHC and CD83 or CD163 positive
sub-populations: Dr. M. Erkan, Dr. D. Stangel,
€60.000
EU FP7: Targeting the tumour microenvironment to improve pancreatic cancer
prognosis (EPC-TM-Net); EU FP7; 2011-2013; €270.000. Prof. J Kleeff, Dr. M. Erkan,
Dr. C.W. Michalski, Prof. I. Esposito, Prof. H. Friess.
2
Memberships

International Hepato-Pancreato-Biliary Associaton (IHPBA / E-AHPBA)

International Association of Pancreatology (IAP)

European Pancreatic Club (EPC)

Deutscher Pankreasclub (DPC)

Istanbul Chamber of Medicine

Turkish Association of Hepato-Pancreato-Biliary Surgery

EDS – European Digestive Surgery

DGAV – Deutsche Gesellschaft für Allgemein- und Viszeralchirurgie

Deutscher Modellflieger Verband e.V.
Congress Organisations

th
5 European Congress of the International Hepato-Pancreato-Biliary Association (IHPBA).
28.-31. May 2003, Istanbul, Turkey

th
6 Congress of the European Hepato-Pancreato-Biliary Association (EHPBA). 25.-28.
May 2005, Heidelberg

31. Deutscher Pankreasclub, 18.-20. November 2010, Munich

1 meeting of the Pancreatic Star Alliance. Consensus Meeting on Pancreatic Stellate
st
Cells. 04. März 2011, Munich- Congress Preisdent

Pankreas-Symposium. 16 May 2013. Klinikum rechts der Isar, Tecnische Universität
München. Munich, Germany.

Consensus Workshop on Defining and Standardizing Pancreatic Texture. 30.05.13 –
th
th
st
14:00 – 17:30, Room III. 10 Congress of the E-AHPBA, 29 – 31 May, 2013, Belgrade,
Serbia. Belgrade

United European Gastroenterology (UEG) Basic Science Course 17
th
th
– 19 July, 2014,
Klinikum r.d. Isar, Technische Universität München, Munich, Germany
Invited Faculty and Chair

th
5 European Congress of the IHPBA, 28.-31. May 2003, Istanbul, Turkey.
Poster-Session: Hepato-Pancreato-Biliary, Chairman

th
6 Congress of the European Hepato-Pancreato-Biliary Association (EHPBA)
25.-28. May 2005, Heidelberg. Session: Hydatid Liver Disease, State of the art lecture:
“Laparoscopic cyst- and pericystectomy”

31. Deutscher Pankreasclub, 18.-20. November 2010, Munich, State of the art lecture:
“Microenvironment of the pancreatic cancer”

First meeting of the Pancreatic Star Alliance. Consensus Meeting on Pancreatic Stellate
Cells: Does EMT contribute to the population of PSC?

First meeting of the Pancreatic Star Alliance. Consensus Meeting on Pancreatic Stellate
Cells: Purity and contaminants of PSC isolated by different methods
3

32. Deutscher Pankreasclub, 17.-19. November 2011, Marburg, Importance of Stroma in
inflammation and tumorigenesis. Chairmen: C. Pilarsky, M. Erkan

EDS Postgraduate Course – Advances in Gastro-Intetinal Surgery, November 24-26,
2011, Lublin, Poland. Video Session: Surgical options in Klatskin tumors

th
6 EDS Postgraduate Course – Advances in Gastro-Intetinal Surgery, April 19-21 2012,
Thessaloniki, Greece. Incidental carcinoma of the gallbladder: How to deal with it?

Viszelmedizin
2012,
Gastroenterologie-Viszeralchirurgie
19.-22.
September
2012,
Hamburg, Germany. AG Pankreas: StellaTUM: Report about the consensus conference

Viszelmedizin
2012,
Gastroenterologie-Viszeralchirurgie
19.-22.
September
2012,
Hamburg, Germany. Interactions of pancreatic stellate cells with cancer cells

2012 Joint APA/IAP Annual Meeting, October 31 - November 3, 2012 – Miami, Florida,
USA: Mini Symposium: Pancreatic stellate cells and cancer

XVI. Annual Meeting of the European Society of Surgery, November 22-24, 2012 Istanbul.
Chair: Invited Presentations, 08:00-09:30, 23.11.12

XVI. Annual Meeting of the European Society of Surgery, November 22-24, 2012 Istanbul.
Chair: An Ordinary Day in the Theatre, 16:00-17:00, 24.11.12

th
7 EDS Postgraduate Course – Pitfalls in Gastro-Intestinal Surgery, May 9-11 2013,
Istanbul, Turkey. Colorectal cancer management. Case presentations. 10:30-11:30,
11.05.13

th
th
st
10 Congress of the E-AHPBA, 29 – 31 May, 2013, Belgrade, Serbia
Breakfast Session: How to do a pancreatic anastomosis? Helmut Friess and Mert Erkan
07:45 – 08:45, 30.05.13

th
th
st
10 Congress of the E-AHPBA, 29 – 31 May, 2013, Belgrade, Serbia: Chair: Session 8:
Oral presentations – Pancreas: 30.05.13, 09:00 – 10:00, Amfiteatar, Alain Sauvanet, Mo
Hilal, Mert Erkan

th
th
st
10 Congress of the E-AHPBA, 29 – 31 May, 2013, Belgrade, Serbia: Chair: Session
29: Oral presentations – Pancreas: 14:00 – 15:30 , Room IV-1 , Helmut Friess, Mert
Erkan, Takashi Hatori

th
10
th
Congress of the E-AHPBA, 29
st
– 31
May, 2013, Belgrade, Serbia. Belgrade
Consensus Workshop on Defining and Standardizing Pancreatic Texture. 30.05.13 –
14:00 – 17:30, Room III.

Onkologisch-chirurgische Viszeralmedizin Kompetenz unter einem Dach. 29.06.2013.
Klinkum rechts der Isar, Technische Universität München, Munich, Germany. Grenzwertig
resektable Pankreaskarzinome - Grenzen der chirurgischen Therapie

Surgical Treatment of Borderline Resectable Pancreatic Cancer, East China Surgery
Congress, June 6th-8th, 2014, Hefei, Anhui Province in P.R. of China

United European Gastroenterology (UEG) Basic Science Course 17
th
th
– 19 July, 2014,
Klinikum r.d. Isar, Technische Universität München, Munich, Germany: The impact of
th
stroma on carcinogenesis. 18 July, 2014, 08:30 – 09:00.
4
Reviewer for: (among others)

BMC Gastroenterology

Carcinogenesis

Gastric Cancer (Editorial Board Member)

Gastroenterology

Gut

Journal of Pancreatology

Lancet Oncology

Molecular Oncology

Pancreatology

The Journal of Pathology

Türkiye Klinikleri Journal of Medical Sciences

Trials
5
Publications
1. Erkan M, Kleeff J, Esposito I, Giese T, Ketterer K, Buchler MW, Giese NA, Friess H. Loss of
BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and
worsened prognosis. Oncogene. 2005 Jun 23;24(27):4421-32.
2. Erkan M, Tekant Y. Molecular aspects of pancreatic cancer and new threapeutic targets
(review in Turkish). Türk HPB 2005;1(2):1-5.
3. Ceyhan GO, Giese NA, Erkan M, Kerscher AG, Wente MN, Giese T, Büchler MW, Friess H.
The neurotrophic factor Artemin promotes pancreatic cancer invasion: Ann surg. 2006; 244:
274-281.
4. Ceyhan GO, Bergmann F, Kadihasanoglu M, Erkan M, Park W, Gorbachevski A,
Buchler
MW, Giese N, Friess H. The neurotrophic factor artemin influences the extent of neural
damage and growth in chronic pancreatitis. Gut. 2007; 56:534-44.
5. Erkan M, Kleeff J, Gorbachevski A, Reiser C, Mitkus T, Esposito I, Giese T, Buchler MW,
Giese NA, Friess H. Periostin creates a tumor supportive microenvironment in the pancreas
by sustaining fibrogenic steallate cell activity. Gastroenterology. 2007; 132:1447-64.
6. Weiwei Zhang, Mert Erkan, Ivane Abiatari, Nathalia A. Giese, Klaus Felix, Hany Kayed,
Markus W. Büchler, Helmut Friess, Jörg Kleeff. Expression of Extracellular
Matrix Metalloproteinase Inducer (EMMPRIN/CD147) in Pancreatic Neoplasm and
Pancreatic Stellate Cells. Cancer Biol Ther. 2007; 6:218-27.
7. Kussumawidjaja G, Kayed H, Bauer A, Giese N, Erkan M, Friess H, Kleeff J. Basic
transcription factor 3 (BTF3) regulates transcription of tumor-associated genes in pancreatic
cancer cells. Cancer Biol Ther. 2007; 6:367-76.
*
*
*
8. Michalski CW , Oti FE , Erkan M , Bergmann F, Pacher P, Batkai S, Müller MW, Giese NA,
Friess H, Kleeff J. Cannabinoids in pancreatic cancer: correlation with survival and pain. Int J
Cancer. 2008;122(4):742-50.
* Equally contributing first author
9. Erkan M, Kleeff J, Reiser C, Hinz U, Esposito I, Friess H, Büchler MW. Pre-operative acute
pancreatitis in periampullary tumors: Implications for surgical management. Digestion. 2007
Aug 7; 75:165-171
10. Michalski CW, Kleeff J, Bachmann J, lKhatib J, Erkan M , Esposito I, Friess H, Büchler MW.
Second-look operation for unresectable pancreatic ductal adenocarcinoma at a high-volume
center. Ann Surg Oncol. 2008; 15(1):186-92. Epub 2007 Oct 18.
11. Michalski CW*, Gorbachevski A*, Erkan M*, Reiser C, Deucker S, Bergmann F, Giese T,
Weigand M, Giese NA, Friess H, Kleeff J. Mononuclear cells modulate the activity of
pancreatic stellate cells which in turn promote fibrosis and inflammation in chronic pancreatitis.
J Transl Med. 2007 Dec 5;5(1):63
* Equally contributing first author
12. Hüser N, Michalski CW, Erkan M, Schuster T, Rosenberg R, Kleeff J, Friess H. Systematic
review and meta-analysis of the role of defunctioning stoma in low rectal cancer surgery: Is it
needed? Ann Surg. 2008 Jul;248(1):52-60. Review.
13. Michalski CW*, Maier M* Erkan M*, Sauliunaite D, Bergmann F, Pacher P, Batkai S, Giese
NA, Giese T, Friess H, Kleeff J. Cannabinoids reduce markers of inflammation and fibrosis in
pancreatic stellate cells. PLoS ONE. 2008 Feb 27;3(2):e1701.
* Equally contributing first author
6
14. Reiser-Erkan C, Erkan M, Michalski CW, Bekasi S, Giese NA, Giese T, Friess H, Kleeff J.
Expression of hypoxia-inducible proto-oncogene Pim-1 in pancreatic neoplasms. Cancer Biol
Ther. 2008; 9:1353-1360
15. Erkan M, Michalski CW, Rieder S, Reiser-Erkan C, Abiatari I, Kolb A, Giese NA, Esposito I,
Friess H, Kleeff J. Activated stroma index is a novel and independent prognostic marker in
pancreatic ductal adenocarcinoma. Clin Gastroenterol Hepatol. 2008 Oct;6(10):1155-61. Epub
2008 Jul 17
16. Michalski CW, Erkan M, Hüser N, Müller MW, Hartel M, Friess H, Kleeff J. Resection of
primary pancreatic cancer and liver metastasis: a systematic review. Dig Surg.
2008;25(6):473-80. Epub 2009 Feb 12.
17. Michalski CW*, Erkan M*, Sauliunaite D, Giese T, Stratmann R, Sartori C, Giese NA, Friess
H, Kleeff J. Ex vivo chemosensitivity testing and gene expression profiling predict response
towards adjuvant gemcitabine treatment in pancreatic cancer. Br J Cancer. 2008 Sep
2;99(5):760-7.
* Equally contributing first author
18. Jiang X, Abiatari I, Kong B, Erkan M, De Oliveira T, Giese NA, Michalski CW, Friess H, Kleeff
J. Pancreatic Islet and Stellate Cells Are the Main Sources of Endocrine Gland-Derived
Vascular Endothelial Growth Factor/Prokineticin-1 in Pancreatic Cancer. Pancreatology. 2008
Dec 13;9(1-2):165-172.
19. Streit S, Michalski CW, Erkan M, Kleeff J, Friess H. Northern blot analysis for detection and
quantification of RNA in pancreatic cancer cells and tissues. Nat Protoc. 2009;4(1):37-43.
20. Ceyhan GO, Deucker S, Demir IE, Erkan M, Schmelz M, Bergmann F, Müller MW, Giese T,
Büchler MW, Giese NA, Friess H. Neural fractalkine expression is closely linked to pain and
pancreatic neuritis in human chronic pancreatitis. Lab Invest. 2009 Mar;89(3):347-61.
21. Erkan M, Reiser-Erkan C, Michalski CW, Deucker S, Sauliunaite D, Streit S, Esposito I,
Friess H, Kleeff J. Cancer-stellate cell interactions perpetuate the hypoxia-fibrosis cycle in
pancreatic ductal adenocarcinoma. Neoplasia. 2009 May;11(5):497-508.
22. Streit S, Michalski CW, Erkan M, Friess H, Kleeff J. Confirmation of DNA Microarray-Derived
Differentially Expressed Genes in Pancreatic Cancer Using Quantitative RT-PCR.
Pancreatology. 2009 Aug 4;9(5):577-582.
23. Pan Z, Erkan M, Streit S, Friess H, Kleeff J. Silencing of GRP94 expression promotes
apoptosis in pancreatic cancer cells. Int J Oncol. 2009 Oct;35(4):823-8.
24. Michalski CW, Erkan M, Friess H, Kleeff J. Tumor metabolism to blood flow ratio in pancreatic
cancer: helpful in patient stratification. Future Oncol. 2010 Jan;6(1):13-5.
25. Ceyhan GO, Schäfer KH, Kerscher AG, Rauch U, Demir IE, Kadihasanoglu M, Böhm C,
Müller MW, Büchler MW, Giese NA, Erkan M, Friess H. Nerve growth factor and artemin are
paracrine mediators of pancreatic neuropathy in pancreatic adenocarcinoma. Ann Surg. 2010
May;251(5):923-31.
26. Erkan M, Weis N, Pan Z, Schwager C,Jiang X, Wirkner X, Giese NA, Ansorge W, Debus J,
Huber PE, Friess H, Abdollahi A, Kleeff J. Organ-, Inflammation- and Cancer Specific
Transcriptional Fingerprints of Pancreatic and Hepatic Stellate Cells. Mol Cancer, 2010 Apr
23;9:88.
27. Holzapfel K, Reiser-Erkan C, Fingerle AA, Erkan M, Eiber MJ, Rummeny EJ, Friess H, Kleeff
J, Gaa J. Comparison of diffusion-weighted MR imaging and multidetector-row CT in the
detection of liver metastases in patients operated for pancreatic cancer. Abdom Imaging. 2011
Apr;36(2):179-84.
7
28. Reiser-Erkan C, Erkan M, Ulbrich E, Nahrig J, Kleeff J. Cystic colon duplication causing
intussusception in a 25-year-old man: report of a case and review of the literature. BMC Surg.
2010 Jun 23;10(1):19.
29. Kong B, Michalski CW, Hong X, Valkovska N, Rieder S, Abiatari I, Streit S, Erkan M, Esposito
I, Friess H, Kleeff J. AZGP1 is a tumor suppressor in pancreatic cancer inducing
mesenchymal-to-epithelial transdifferentiation by inhibiting TGFbeta-mediated ERK signaling.
Oncogene. 2010 Sep 16;29(37):5146-58.
30. Wang W, Reiser-Erkan C, Raggi MC, Michalski CW, Quan L, Yupei Z, Friess H, Erkan M ,
Kleeff J. BHLHB2 overexpression is a positive prognostic factor indicating gemcitabine
responsiveness in pancreatic cancer. Biochem Biophys Res Commun. 2010 Oct
22;401(3):422-8
31. Samkharadze T*, Erkan M*, Reiser-Erkan C, Demir IE, Bo K, Ceyhan GO, Michalski CW,
Esposito I, Friess H, Kleeff J. Pigment Epithelium-Derived Factor Increases Neuropathy and
Fibrosis in Pancreatic Cancer. Am J Gastroenterol. 2011 Jan 11 [Epub ahead of print].
* Equally contributing first author
32. Erkan M, Reiser-Erkan C, Michalski CW, Friess H, Kleeff J. Tumor microenvironment and
progression of pancreatic cancer. Exp Oncol. 2010 Sep;32(3):128-31
33. Erkan M, Tekant Y. Intraductal Papillary Mucinous Neoplasms of the Pancreas. (Review in
Turkish). In press 2011.
34. Paron I, Berchtold S, Vörös J, Shamarla M, Erkan M, Höfler H, Esposito I. Tenascin-C
Enhances Pancreatic Cancer Cell Growth and Motility and Affects Cell Adhesion through
Activation of the Integrin Pathway. PLoS One. 2011;6(6):e21684. Epub 2011 Jun 29.
35. Kong B, Michalski CW, Erkan M, Friess H, Kleeff J. From tissue turnover to the cell of origin
for pancreatic cancer. Nat Rev Gastroenterol Hepatol. 2011 Jul 12;8(8):467-72.
36. Erkan M, Adler G, Apte MV, Bachem MG, Buchholz M, Detlefsen S, EspositoI, Friess H,
Gress T, Habisch HJ, Hwang RF, Jaster R, Kleeff J, Klöppel G, Kordes C, Logsdon CD,
Masamune A, Michalski CW, Oh J, Phillips PA, Pinzani M, Reiser-Erkan C, Tsukamoto H,
Wilson J. StellaTUM: Current consensus and discussion on pancreatic stellate cell research.
Gut. 2012 Feb;61(2):172-8.
* All authos have contribute equally
37. Erkan M*, Reiser-Erkan C*, Michalski CW, Kong B, Esposito I, Friess H, Kleeff J. The impact
of the activated stroma on pancreatic ductal adenocarcinoma biology and therapy resistance.
Curr Mol Med. 2012 Mar 1;12(3):288-303.
* Equally contributing first author
*
*
38. Herrmann K. , Erkan M. , Dobritz M., Schuster T., Siveke J.T., Beer A.J., Wester H.J., Schmid R.M.,
Friess H., Schwaiger M., Kleeff J., Buck A.K. Comparison of 3'-deoxy-3'-[18F]fluorothymidine
positron emission tomography (FLT-PET) and FDG-PET/CT for the detection and characterization of
pancreatic tumors. Eur J Nucl Med Mol Imaging. 2012 May;39(5):846-51.
* Equally contributing first author
39. Regel I, Kong B, Raulefs S, Erkan M, Michalski CW, Hartel M, Kleeff J. Energy metabolism
and proliferation in pancreatic carcinogenesis. Langenbecks Arch Surg. 2012 Apr;397(4):50712.
40. De Oliveira T, Abiatari I, Raulefs S, Sauliunaite D, Erkan M, Kong B, Friess H, Michalski CW,
Kleeff J. Syndecan-2 promotes perineural invasion and cooperates with K-ras to induce an
invasive pancreatic cancer cell phenotype. Mol Cancer. 2012 Apr 3;11(1):19
41. Mihaljevic AL, Michalski CW, Erkan M, Reiser-Erkan C, Jaeger C, Schuster T, Schuhmacher
C, Kleeff J and Friess H. Standard abdominal wound edge protection with surgical dressings
8
vs coverage with a sterile circular polyethylene drape for prevention of surgical site infections
(BaFO): study protocol for a randomized controlled trial. Trials. 2012 May 15;13:57.
42. Erkan M, Hausmann S, Michalski CW, Fingerle AA, Dobritz M, Kleeff J, Friess H. The role of
stroma in pancreatic cancer: diagnostic and therapeutic implications. Nat Rev Gastroenterol
Hepatol. 2012 Aug;9(8):454-67.
43. Erkan M, Hausmann S, Michalski CW, Schlitter AM, Fingerle AA, Dobritz M, Friess H, Kleeff
J. How fibrosis influences imaging and surgical decisions in pancreatic cancer. Front Physiol.
2012;3:389.
44. Erkan M. Antifibrotic therapy in pancreatic diseases. Gut. 2012 Dec 22. [Epub ahead of print]
45. Erkan M. Pancreatic stellate cells and cancer. Pancreatology, 2013 Mar-Apr;13(2):106-9.
46. Li N, Wu X, Holzer RG, Lee JH, Todoric J, Park EJ, Ogata H, Gukovskaya AS, Gukovsky I,
Pizzo DP, Vandenberg S, Tarin D, Atay C, Arkan MC, Deerinck TJ, Moscat J, Diaz-Meco M,
Dawson D, Erkan M, Kleeff J, Karin M. Loss of acinar cell IKKα triggers spontaneous
pancreatitis in mice. J Clin Invest. 2013 May 1;123(5):2231-43.
47. Erkan M. Understanding the stroma of pancreatic cancer: Coevolution
microenvironment with the epithelial carcinogenesis. J Pathol. 2013 May 28
of
the
48. Stellwag T, Michalski CW, Kong B, Erkan M, Reiser-Erkan C, Jäger C, Meinl C, Friess H,
Kleeff J. Comparative analysis of the revenues of pylorus-preserving pancreatic head
resections and laparoscopic cholecystectomies as prototypic surgical procedures in the
German health care system. Langenbecks Arch Surg, 2013 Aug;398(6):825-31
49. Kong Bo, Qia C, Erkan M, Kleeff J, Michalski CW. Overview on how oncogenic Kras promotes
pancreatic carcinogenesis by inducing low intracellular ROS levels. Front Physiol. 2013 Sep
12;4:246
50. Balic A, Dræby Sørensen M, Trabulo SM, Sainz B Jr, Cioffi M, Vieira CR, Miranda-Lorenzo I,
Hidalgo M, Kleeff J, Erkan M, Heeschen C. Chloroquine targets pancreatic cancer stem cells
via inhibition of CXCR4 and hedgehog signaling. Mol Cancer Ther. 2014 Jul;13(7):1758-71.
51. Hausmann S, Kong B, Michalski C, Erkan M, Friess H. The role of inflammation in pancreatic
cancer. Adv Exp Med Biol. 2014;816:129-51.
52. Yalcin S, Erkan M, Ünsoy G, Parsian M, Kleeff J, Gündüz U. Effect of gemcitabine and
retinoic acid loaded PAMAM dendrimer-coated magnetic nanoparticles on pancreatic cancer
and stellate cell lines. Biomedicine & Pharmacotherapy, 2014, in press.
9
Book Chapters
1. Friess H, Erkan M, Kleeff J, Haberkorn U, Buchler MW. The role of PET in diagnosis of
pancreatic cancer and recurrence. The Pancreas: 2008. Eds. H.G. Beger, A.L. Warshaw,
R.C.G. Russell, M. Buchler, D. Carr Locke, J.Neoptolemos, M.G. Sarr.
2. Friess H, Kleeff J, Erkan M, Buchler MW. Palliative pancreatico-duodenectoy. The Pancreas:
2008. Eds. H.G. Beger, A.L. Warshaw, R.C.G. Russell, M. Buchler, D. Carr Locke,
J.Neoptolemos, M.G. Sarr.
3. Mert Erkan, Helmut Friess, Jörg Kleeff. Apoptosis. In: “Molecular Biology of Cancer”, , 2008.
Ed. S. Ossinsky.
4. Erkan M, Esposito I, Friess H, Kleeff J. Tumor-Stromal Interaction: Invasion and Metastasis.
Handbook of Pancreatic Cancer: 2009. Eds: J.P. Neoptolemos, R. Urrutia, J.L. Abbruzzese,
M.W. Büchler.
5. F. Kolligs, M. Erkan, A. Graser, S. Haraida, T. Helmberger, B. Neu, M. op den Winkel, C.
Trumm, C. Tympner, M. Rentsch. Hepatozelluläres Karzinom, Manual: Gastrointestinale
Tumoren, Tumorzentrum München. 9. Auflage 2013
6. Mert Erkan, Tania Brocks, Helmut Friess. The Role of Non-cancerous Cells in Cancer:
Pancreatic Ductal Adenocarcinoma as a Model to Understand the Impact of Tumor
Microenvironment on Epithelial Carcinogenesis. Cancer Targeted Drug Delivery. 2013 Eds:
You Han Bae, Randall J. Mrsny, Kinam Park.
7. Simone Hausmann, Bo Kong, Christoph Michalski, Mert Erkan and Helmut Friess. Role of
Inflammation in Pancreatic Cancer. Advs Exp. Medicine, Biology, Vol. 816, Inflammation and
Cancer. 2014, in press, Eds: Bharat B. Aggarwal et al.
10