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Milestones of
Medical Ozone
Renate Viebahn-Hänsler, Iffezheim
22.03.02
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Milestones of Medical Ozone
Ozone Treatment in Surgery
§
§
§
§
§
§
Werkmeister
1915 A. Wolff,
Berlin,Germany
1935 E. Payr,
Leipzig, Germany
1937 P. Aubourg,
Paris, France
1977 O. Rokitansky,
Vienna, Austria
1981 H. Werkmeister,
Oberhausen, Germany
1987 H.G. Knoch,
Dresden, Germany
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Milestones of Medical Ozone
Ozononised Water in Dental Medicine
§ 1935
E.A. Fisch,
Locarno, Switzerland
§ 1976
R. Türk,
Bad Pyrmont, Germany
§ 1991
H. Kirschner,
Giessen,Germany
A. Filippi, Basel, Switzerland
Brauner
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Milestones of Medical Ozone
Applications: Topical Treatments 2
§
Transcutanous gas bath in
ozone resistent plastic bags
§
1958 J. Hänsler, H. Wolff,
Iffezheim/ Frankfurt,Germany
Indications:
- Ulcus cruris,
- Dermatosis,
- Fungus infections
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Milestones of Medical Ozone
Applications: Topical Treatments 1
§
§
Low pressure ozone
gas application
1981 H. Werkmeister
Oberhausen, Germany
Indications:
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RV OZONOSAN
Decubitus ulcers,
Diabetic gangrene,
Fistulas and
Badly healing wounds
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Milestones in Medical Ozone
Applications: Rectal Insufflation
§ 1937 P.Aubourg,
Paris, France
§ 1987 H.G. Knoch,
Dresden, Germany
Indications:
-
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RV OZONOSAN
Proctitis
Colitis
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Milestones in Medical Ozone
Applications: Major Autohaemotherapy
§ Major Autohaemotherapy
as extracorporeal blood
treatment avoiding intravascular gas application
forms.
§ 1968
H. Wolff,
Frankfurt, Germany
Indications:
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RV OZONOSAN
Arterial circulatory disorders
Immunomodulation
Rheumatoid arthritis
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Milestones of Medical Ozone
Applications:
Intraarticular Injections in Orthopedics
§ 1981
Z. Fahmy,
Bad Kreuznach, Germany
§ 1989
E. RivaSanseverino,
Bologna, Italy
Indications:
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Knee arthrosis,
Gonarthrosis
and rheumatoid arthritis
as supportive therapy
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Milestones of Medical Ozone
Pharmacological Effects 1: Red Blood Cells
Oxygen saturation
§
§
§
§
1975 Buckley et al.
1979 Freeman et al.
1977-1986 Washüttl et al.
2001 Lell et al.
§
Peroxide formation and
activation of the RBCmetabolism via the
glutathion system with
improvement of oxygen
release
without DPG
with DPG
Oxygen partial pressure pO2 in mm Hg
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Milestones of Medical Ozone
Pharmacological Effects 2: immunocompetent cells
§ 1990 Bocci et al.
§ Induction of cytokins
Cytokin induction in % dep.on O3-conc.
450
400
350
oxygen
300
250
11 µg
200
25 µg
150
42 µg
100
50
0
such as interferons,
interleukins and
growth factors
78 µg
IFN-γ
IFN-g
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IL-6
TNF-α
TNF-a
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Milestones of Medical Ozone
Pharmacological Effects 3: Radical Scavengers
70
Protective effect of ozone in
60
Hepatic Ischaemia - Reperfusion
50
40
30
20
10
0
H2O2
Kontrolle
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SOD
Ischaemia/Reperfusion
§
§
1998 León, Bocci et al.
1999 Peralta et al.
§
Activation of
antioxidative enzymes
and radical scavengers
as protective effect in
damage by free radicals
GSH
Ozone+I/R
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Milestones in Medical Ozone
Pharmacological Effects 4: Ozone and Prevention
Survival rate in lethal septic peritonitis
§ 1999 Schulz et al.
100%
80%
-
60%
40%
20%
0%
ozone
III
anibiotic
IV
O3+antib.
V
-
control
Parasitaemia in %
§ 2001 Lell et al.
35
-
30
25
20
15
10
5
0
day 1
day 2
Parasites
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Improvement of survival rate
in septic peritonitis in an
animal model by
pretreatment with ozone.
Synergistic effect with
antibiotics.
day 3
day 4
day 5
Growth inhibitory effect of
plasmodium in infected
RBC´s by pretreatment with
ozone.
day 6
Ozone+Par.
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Indications of Ozonetherapy Today and
the Pharmacological Background
Indications
Mechanism of Action
§
§
Disinfection, wound cleansing
§
§
§
External ulcers and skin
lesions
Arterial circulatory disorders
Immunodeficiency and
immunodisbalance
Inflammatory conditions
§
Dental Medicine
§
Activation of RBC-metabolism
Activation of immunocompetent
cells
Activation of antioxidants and
radical scavengers
Disinfection, woundhealing
§
§
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