TOLGA ACUN Educational Background Professional Positions

TOLGA ACUN Educational Background Professional Positions

CURRICULUM VITAE
TOLGA ACUN
Nationality
Birth Place / Date
Marital Status
Address
Office Tel.
e-mail
Languages
: Turkish
: Ankara , TURKIYE / 1974
: Single
: Department of Molecular Biology and Genetics,
Faculty of Sciences and Arts,
Bülent Ecevit University,
67100 / Zonguldak / TURKEY
: +90.372.2574010 (internal: 1778)
: [email protected]
[email protected]
: Turkish (Native), English (fluent)
Educational Background
2003-2010
2000-2003
[ 1998-1999 ]
Ph.D.
Bilkent University, TURKEY
Department of Molecular Biology and Genetics
Supervisor : Prof. Dr. M.C. YAKICIER
Thesis Title : Genetic and Epigenetic Evaluation of the Candidate Genes
in Human Hepatocellular Carcinomas
M.Sc.
Middle East Technical University (M.E.T.U), TURKEY
Department of Biology
Supervisor : Prof. Dr. Fatih IZGU
Thesis Title : Isolation and characterization of the K4 type yeast killer toxin
Preparatory School in English at M.E.T.U / TURKEY
[ 1997-1998 ] Obligatory Military Service
1991-1996
B.Sc.
Ankara University, TURKEY
Department of Biology
Professional Positions
2013-(present) Assistant Prof. Dr.
Bülent Ecevit University, Dep. of Molecular Biology and Genetics / Turkey
2012
Visiting Scientist (3 months)
* Council of Higher Education (Turkey) bursarie
Vall d’Hebron Research Institute (VHIR), Barcelona / Spain
2011-2013
Assistant Prof. Dr.
Bülent Ecevit University, Department of Biomedical Engineering / Turkey
2003-2010
Teaching/Research Assistantship
Bilkent University, Department of Molecular Biology and Genetics / Turkey
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TOLGA ACUN, Ph.D.
Administrative Duties
2013
Founding Member
Undergraduate program of "Molecular Biology and Genetics"
Department of Molecular Biology and Genetics,
Faculty of Sciences and Arts, Bülent Ecevit University
2013-(present) Institutional Vice Coordinator,
Mevlana Exchange Programme / Bülent Ecevit University
2013-(present) Vice Head,
Department of Molecular Biology and Genetics
2013-(present) Departmental Coordinator,
Erasmus, Farabi and Mevlana Exchange Programmes
2012-2013
Vice Head,
Department of Biomedical Engineering
Research Interests : Cancer genetics, epigenetic mechanisms
Publications
1. Soysal Y#, Acun T#, Lourenço CM, Marques W Jr, Yakıcıer MC; (2012), “Muscle
Hemangiomatosis Presenting As A Severe Feature In A Patient With The PTEN Mutation:
Expanding The Phenotype Of Vascular Malformations In Bannayan-Riley-Ruvalcaba
Syndrome” BJMG, 15/1, 45-50, (2012) (SCI-Expanded)
#
The first two authors have contributed equally this study.
•
http://www.bjmg.edu.mk/record.asp?recordid=598
2. Tolga Acun, Emin Oztas, Tamer Yagci, Mustafa C Yakicier; (2011), “SIP1 is Downregulated in
Hepatocellular Carcinoma by Promoter Hypermethylation”
BMC Cancer, 11:223, (2011) (SCI-Expanded)
• Listed as “Highly accessed” in BMC CANCER (more than 800 download in first 3 weeks)
• http://www.biomedcentral.com/1471-2407/11/223
3. Acun T, Terzioğlu-Kara E, Konu O, Ozturk M, Yakicier MC; (2010), “Mdm2 Snp309 G allele
displays high frequency and inverse correlation with somatic P53 mutations in hepatocellular
carcinoma”; Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis,
68: 106–108, (2010) (SCI)
• http://dx.doi.org/10.1016/j.mrfmmm.2009.11.008
4. Fatih İzgü, Demet Altınbay and Tolga Acun; (2006), “Killer toxin of Pichia anomala NCYC
432; purification, characterization and its exo-β-1,3-glucanase activity”;
Enzyme and Microbial Technology, 39(4): 669-676, (2006) (SCI)
• http://dx.doi.org/10.1016/j.enzmictec.2005.11.024
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TOLGA ACUN, Ph.D.
Manuscripts
1. Tolga Acun, Emin Oztas, M. Cengiz Yakicier; “PTPRD is homozygously deleted and
epigenetically downregulated in human hepatocellular carcinomas” (Manuscript is ready for
submission to European Journal of Cancer).
Proceedings
1. T. Acun, K. Demir, E. Oztas, M.C. Yakicier; (2012) “Genetic and Epigenetic Alterations of
PTPRD in Hepatocellular Carcinoma”; European Journal of Cancer, vol. 48, suppl. 5 (2012),
ISSN 0959-8049, S25–S288, S123. [22nd Biennial Congress of the European Association for
Cancer Research, 7–10 July 2012, Barcelona, Spain]
2. Y. Soysal, T. Acun, C. M. Lourenço, W. Marques Jr, C. Yakıcıer; (2012) “Muscle
hemangiomatosis as a severe presenting feature in a patient with PTEN mutation: Expanding the
phenotype of vascular malformations in Bannayan-Riley-Ruvalcaba syndrome”; European
Journal of Human Genetics, Volume 20, Supplement 1, June 2012, page 58, P02.038
[European Human Genetics Conference 2012, June 23 - 26, 2012, Nürnberg, Germany]
3. CB Akyerli, D Agirbasli, T Acun, O Sahin, MC Yakicier; (2010) “Analysis of genetic variations
caused by environmental factor aflatoxin in hepatocellular carcinoma”; Clinical Genetics 2010;
78 (Suppl. 1): 57–77 [ Clinical Genetics Special Issue: Abstracts of the 9th National Medical
Genetics Congress, 1-5 December 2010, Istanbul, Turkey ]
4. D Agirbasli, CB Akyerli, T Acun, A Keller, MC Yakicier; (2010) “Lincrna Expression in
Hepatocellular Carcinoma”; Clinical Genetics 2010; 78 (Suppl. 1): 57–77 [ Clinical Genetics
Special Issue: Abstracts of the 9th National Medical Genetics Congress, 1-5 December 2010,
Istanbul, Turkey ]
5. M. Yakicier, T. Acun, S. Dizlek, A. Timuragaoglu; (2009) “A branched dna-based technique for
detection of BCR-ABL gene products”; Haematologica-The Hematology Journal ;
94[suppl.2]:17 abs. 0041, 2009 (14th Annual Meeting of the European-Hematology-Association,
Jun 2009, Berlin, Germany)
6. Tolga Acun, Ece Terzioğlu, Ozlen Konu, Mehmet Ozturk and M. Cengiz Yakicier; (2007)
“MDM2 SNP309 G allele and TP53 mutations are mutually exclusive in human
hepatocellular carcinomas”; ILCA Annual Conference, Book of Abs., p.21, Oct. 2007,
Barcelona / Spain
7. Acun T. and Yakicier M.C.; (2006) "Genetic analysis of hepatocellular carcinoma candidate
tumor supressor genes and oncogenes"; FEBS Journal Volume 273, Issues1, Page 368-371,
Jun 2006 (31st FEBS Congress,"Molecules in Health and Disease", June 2006, Istanbul /
Turkey)
8. F.İzgü, D. Altınbay, T. Acun; (2003) “Isolation and characterization of K4 type yeast
killer protein”; Society for General Microbiology, 153rd Meeting, 2003, UMIST,
Manchester.
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TOLGA ACUN, Ph.D.
Other Congress & Workshops
• Bioinformatics for AntiCancer Drug Discovery Workshop, 17-18 October 2011, Bilkent
Üniversitesi, Ankara / Turkey
•
Sumru Bayın, Zeynep Tokcaer Keskin, Tolga Acun, Mustafa Cengiz Yakıcıer, Kamil Can
Akçalı (2010); “Flt3 may function as a link between liver regeneration and hepatocellular
carcinogenesis” EASL Monothematic Conference, Feb 2010,
Amsterdam / The Netherlands
•
Tolga Acun, M. Cengiz YAKICIER; (2008) “Genetic and Epigenetic Analysis of Epithelial
Cell Senescence Pathway Genes in Hepatocellular Carcinoma” 8th National Medical Genetic
Congress with International Participation, May 2008, Canakkale / Türkiye
* Best Study Award (Oral Presentation)
•
“RNA in Disease and Therapy”; (2006) International University of Andalusia Workshops
“Current Trends in Biomedicine”, October 2006, Baeza / Spain
•
Acun T., Kaya K.D., Konu Ö. and Yakicier M.C.; (2006) "Prediction of new Fugu rubripes
miRNAs" Workshop on "Emerging Topics in Human Functional Genomics and
Proteomics", March 2006, Antalya / Turkey
Projects
1.
2.
3.
4.
“Analysis of HLJ1(DNAJB4) as a new biomarker candidate in cancers”,
Bulent Ecevit University, Scientific Research Project (BAP) No: 2013-50737594-01,
2013 – ongoing, Principle Investigator
“Investigation of Molecular Genetic Changes in Hepatocellular Carcinomas”,
TUBITAK* Project No:107S174,
2009, Researcher student (with fellowship from TUBITAK).
“Genetic Analysis of MAPK Pathway in Hepatocellular Carcinomas”,
TUBITAK, Project No: TBAG-HD/134, 106T203,
2008, Researcher student.
“Epithelial Senescence and Cancer”,
TUBITAK, Project No: SBAG-2774/104S045,
2006, Researcher/Specialist.
(
(*)
TUBITAK; Scientific and Technological Research Council of Turkey
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TOLGA ACUN, Ph.D.
Teaching Experience
* Bülent Ecevit University (as an Assistant Prof. Dr.)
•
•
•
BMM105 Biology for Engineers (2012, 2013)
MBG101 General Biology-I (2013)
MBG103 General Biology Laboratory-I (2013)
* Bilkent University (as a Teaching Assistant)
•
•
•
MBG-418 Genomics (2010)
MBG-210 Genetics (2004-2008)
MBG-223 Molecular Genetics (2003)
Lab Skills
•
Molecular Biology techniques
*DNA-RNA isolation, *PCR, *Q-RT-PCR, *multiplex semi-Q-RT-PCR, *RFLP,
*Sodium Bisulfite Treatment, *Combined Bisulfite Restriction Analysis (COBRA),
*Native and SDS Polyacrylamide Gel Electrophoresis
•
Protein assays
*Western Blotting, *immunohistochemistry, *glyco detection, *peptide mapping, *HPLC
Applications (with Perfusion Chromatography Workstation, BioCAD 700E), *isoelectric
focusing, *coomassie blue and silver staining.
•
Cell culture techniques
•
Basic microbiology techniques
•
Maintenance and basic experiments with the model organisms C. elegans, D. melanogaster,
yeast (H. anemola, S. cerevisiae)
•
Small animal handling
* Have an accredited certificate from “Care & Use of Laboratory Animal Course”
Bilkent University, 2010.
•
Bioinformatics tools [ primer design, BLAST, PyMOL, multiple alignment, mutation analysis,
restriction analysis ], and databases [ NCBI, Ensembl, UCSC, Sanger ].
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TOLGA ACUN, Ph.D.
Fellowships and Awards
2012
Visiting Scientist Fellowship from Turkish Council of Higher Education
Duration: 3 months
Host: Diego ARANGO, Ph.D. Head, Group of Molecular Oncology,
Molecular Biology and Biochemistry Research Center, CIBBIM-Nanomedicine,
Vall d'Hebron Hospital Research Institute, Barcelona, SPAIN.
mail: [email protected]
2003-2010
Full Ph.D. fellowship from Bilkent University.
2008
Best Study Award ( Oral Presentation )
8th National Medical Genetic Congress with International Participation,
May 2008, Canakkale / Türkiye
2007-2009
Researcher bursarie ; TUBITAK Project No: 107S174
2007
Student fellowship ; ILCA 1st Annual Conference, (Barcelona / Spain)
2006
Student fellowship ; FEBS 31st Annual Congress, (Istanbul / Turkey)
Memberships
• European Association for Cancer Research (EACR)
• The Association for Molecular Cancer Research, Turkey (MOKAD)
• Molecular Biology Association (MBD)
Hobies
•
Squash, photography, cooking
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TOLGA ACUN, Ph.D.